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Schamroth Pravda N, Cohen T, Klempfner R, et al. Temporal trends in the pre-procedural TIMI flow grade among patients with ST- segment elevation myocardial infarction - From the ACSIS registry. Int J Cardiol Heart Vasc. 2021;36:100868doi: 10.1016/j.ijcha.2021.100868.
Schamroth Pravda, N., Cohen, T., Klempfner, R., Kornowski, R., Beigel, R., Orvin, K., Abitbol, M., Schamroth Pravda, M., Dobrecky-Mery, I., Rubinshtein, R., Saada, M., & Eisen, A. (2021). Temporal trends in the pre-procedural TIMI flow grade among patients with ST- segment elevation myocardial infarction - From the ACSIS registry. International journal of cardiology. Heart & vasculature, 36100868. https://doi.org/10.1016/j.ijcha.2021.100868
Schamroth Pravda, Nili, et al. "Temporal trends in the pre-procedural TIMI flow grade among patients with ST- segment elevation myocardial infarction - From the ACSIS registry." International journal of cardiology. Heart & vasculature vol. 36 (2021): 100868. doi: https://doi.org/10.1016/j.ijcha.2021.100868
Schamroth Pravda N, Cohen T, Klempfner R, Kornowski R, Beigel R, Orvin K, Abitbol M, Schamroth Pravda M, Dobrecky-Mery I, Rubinshtein R, Saada M, Eisen A. Temporal trends in the pre-procedural TIMI flow grade among patients with ST- segment elevation myocardial infarction - From the ACSIS registry. Int J Cardiol Heart Vasc. 2021 Sep 01;36:100868. doi: 10.1016/j.ijcha.2021.100868. eCollection 2021 Oct. PMID: 34504948; PMCID: PMC8413889.
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Int J Cardiol Heart Vasc. 2021 Sep 01;36:100868. doi: 10.1016/j.ijcha.2021.100868. eCollection 2021 Oct.

Temporal trends in the pre-procedural TIMI flow grade among patients with ST- segment elevation myocardial infarction - From the ACSIS registry.

International journal of cardiology. Heart & vasculature

Nili Schamroth Pravda, Tal Cohen, Robert Klempfner, Ran Kornowski, Roy Beigel, Katia Orvin, Merry Abitbol, Miri Schamroth Pravda, Idit Dobrecky-Mery, Ronen Rubinshtein, Madji Saada, Alon Eisen

Affiliations

  1. Department of Cardiology, Rabin Medical Center, Petach Tikva, Israel.
  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  3. Israeli Center of Cardiovascular Research, Tel Hashomer, Israel.
  4. The Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel.
  5. Internal Medicine A, Meir Medical Center, Kfar Saba, Israel.
  6. Bnai Zion Medical Center, Haifa, Israel.
  7. Wolfson Medical Center, Holon, Israel.
  8. Hilel Yaffe Medical Center, Hadera, Israel.

PMID: 34504948 PMCID: PMC8413889 DOI: 10.1016/j.ijcha.2021.100868

Abstract

BACKGROUND: Pre-procedural TIMI coronary flow grade in patients with ST segment elevation myocardial infarction (STEMI) is associated with adverse clinical outcomes. There have been great advances in pharmacologic and invasive treatment of STEMI patients in the current era. We aimed to assess the temporal trends in clinical outcomes according to the TIMI flow grade amongst these patients.

METHODS: Data of patients with STEMI from the acute coronary syndrome Israeli Survey (ACSIS) registry. A time-dependent analysis stratifying patient by TIMI flow grade 0 and TIMI flow grade 1-3 was performed. Survey years were divided to early (2008-2010) and late period (2013-2018). Clinical outcomes included in-hospital complications, 30d MACE (death, myocardial infarction, stroke, unstable angina, stent thrombosis, urgent revascularization) and 1-year mortality.Results and Conclusions: Included were 2453 patients. The majority of patients had pre-procedural TIMI flow 0 (58.9% in the early period and 58.7% in the late period, P = 0.97). In-hospital complications of patients with TIMI flow 0 has significantly decreased over time (36.1% vs 26.8%, P < 0.001) but not amongst patients with TIMI flow 1-3. Compared with TIMI flow 1-3, patients with TIMI flow 0 had worse 30d MACE and 1-year mortality. There was no temporal change of these outcomes in either TIMI flow grade group. TIMI flow grade 0 is still more common among patients with STEMI and is associated with poorer prognosis. Nevertheless, over time, in-hospital complications have decreased among patients with TIMI 0, while 30d MACE and 1-year mortality has remained unchanged.

© 2021 The Authors.

Keywords: STEMI; TIMI flow grade; Temporal trends

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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