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Farimani Z, Shamshiri AR, Asl Roosta H, et al. Regenerative benefits of using growth factors in treatment of periodontal defects: A systematic review and meta-analysis with Trial Sequential Analysis on preclinical studies. J Tissue Eng Regen Med. 2021;15(11):964-997doi: 10.1002/term.3241.
Farimani, Z., Shamshiri, A. R., Asl Roosta, H., Akbari, S., & Bohlouli, M. (2021). Regenerative benefits of using growth factors in treatment of periodontal defects: A systematic review and meta-analysis with Trial Sequential Analysis on preclinical studies. Journal of tissue engineering and regenerative medicine, 15(11), 964-997. https://doi.org/10.1002/term.3241
Farimani, Zeinab, et al. "Regenerative benefits of using growth factors in treatment of periodontal defects: A systematic review and meta-analysis with Trial Sequential Analysis on preclinical studies." Journal of tissue engineering and regenerative medicine vol. 15,11 (2021): 964-997. doi: https://doi.org/10.1002/term.3241
Farimani Z, Shamshiri AR, Asl Roosta H, Akbari S, Bohlouli M. Regenerative benefits of using growth factors in treatment of periodontal defects: A systematic review and meta-analysis with Trial Sequential Analysis on preclinical studies. J Tissue Eng Regen Med. 2021 Nov;15(11):964-997. doi: 10.1002/term.3241. Epub 2021 Sep 14. PMID: 34480421.
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J Tissue Eng Regen Med. 2021 Nov;15(11):964-997. doi: 10.1002/term.3241. Epub 2021 Sep 14.

Regenerative benefits of using growth factors in treatment of periodontal defects: A systematic review and meta-analysis with Trial Sequential Analysis on preclinical studies.

Journal of tissue engineering and regenerative medicine

Zeinab Farimani, Ahmad Reza Shamshiri, Hoori Asl Roosta, Solmaz Akbari, Mahboubeh Bohlouli

Affiliations

  1. Department of Periodontics, School of Dentistry, Alborz University of Medical Sciences, Karaj, Iran.
  2. Department of Community Oral Health, School of Dentistry, Research Center for Caries Prevention, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  3. Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
  4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 34480421 DOI: 10.1002/term.3241

Abstract

The ultimate goal in periodontal treatments is to achieve a functional and anatomical regeneration of the lost tissues. Numerous studies have in some way illustrated the beneficial effects of biologic modifiers in this process, yet they are subject to a rather large degree of diversity in their results. Thanks to the promising outcomes of bioengineering techniques in the field of periodontal regeneration, this systematic review aims to evaluate the effect of various biologic modifiers used in periodontal defects of animal models. Electronic databases (Medline, Scopus, Embase, Web of Science, and Google Scholar) were searched (March 2010-December 2020) for every study that used biomolecules for regeneration of periodontal osseous defects in animal models. Regenerated bone height or area, new cementum, new connective tissues, new regenerated periodontal ligament and the dimensions of epithelial attachment (either in mm/mm

© 2021 John Wiley & Sons Ltd.

Keywords: animal model; growth factor; intrabony defects; periodontal regeneration

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