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Matías-Pérez D, Pérez-Santiago AD, Sánchez Medina MA, et al. . Balkan J Med Genet. 2021;24(1):5-14doi: 10.2478/bjmg-2021-0009.
Matías-Pérez, D., Pérez-Santiago, A. D., Sánchez Medina, M. A., Alpuche Osorno, J. J., & García-Montalvo, I. A. (2021). . Balkan journal of medical genetics : BJMG, 24(1), 5-14. https://doi.org/10.2478/bjmg-2021-0009
Matías-Pérez, D, et al. "." Balkan journal of medical genetics : BJMG vol. 24,1 (2021): 5-14. doi: https://doi.org/10.2478/bjmg-2021-0009
Matías-Pérez D, Pérez-Santiago AD, Sánchez Medina MA, Alpuche Osorno JJ, García-Montalvo IA. . Balkan J Med Genet. 2021 Jul 27;24(1):5-14. doi: 10.2478/bjmg-2021-0009. eCollection 2021 Jun. PMID: 34447653; PMCID: PMC8366480.
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Balkan J Med Genet. 2021 Jul 27;24(1):5-14. doi: 10.2478/bjmg-2021-0009. eCollection 2021 Jun.

[No title available]

Balkan journal of medical genetics : BJMG

D Matías-Pérez, A D Pérez-Santiago, M A Sánchez Medina, J J Alpuche Osorno, I A García-Montalvo

Affiliations

  1. Division of Postgraduate Studies and Research, Tecnológico Nacional de México, Instituto Tecnológico de Oaxaca, Oaxaca City, Oaxaca, México.
  2. Faculty of Medicine and Surgery, Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca City, Oaxaca, México.

PMID: 34447653 PMCID: PMC8366480 DOI: 10.2478/bjmg-2021-0009

Abstract

Dyslipidemias are a group of diseases, which are characterized by abnormal blood concentrations of cholesterol, triglycerides and/or low-density lipoprotein-cholesterol (LDL-c). Dyslipidemia is a determinant condition for the progress of an atherosclerotic plaque formation. The resulting atherogenicity is due to at least two mechanisms: first, to the accumulation in the plasma of lipid particles that have the capacity to alter the function of the endothelium and deposit at the atheromatous plaque, and second, at an insufficient concentration of multifactorial type of high density lipoprotein-cholesterol (HDL-c), whose function is to protect against the development of atherosclerosis. Its highest prevalence is encountered among individuals with diabetes, hypertension or overweight. Hyperlipidemia is one of the main predisposing factors for the development of cardiovascular disease. Hyperlipidemia can be the result of a genetic condition, the secondary expression of a primary process or the consequence of exogenous factors (food, cultural, socio-economic,

© 2021 Matías-Pérez D, Pérez-Santiago AD, Sánchez Medina MA, Alpuche Osorno JJ, García-Montalvo IA, published by Sciendo.

Keywords: Cardiovascular diseases; Dyslipidemia; Hyperlipidemia; Proprotein convertase subtilisin/kexin type 9 (PCSK9) gene

Conflict of interest statement

Conflict of interest Declaration of Interest. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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