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J Funct Biomater. 2021 Aug 11;12(3). doi: 10.3390/jfb12030045.

Bioprinting and In Vitro Characterization of an Eggwhite-Based Cell-Laden Patch for Endothelialized Tissue Engineering Applications.

Journal of functional biomaterials

Yasaman Delkash, Maxence Gouin, Tanguy Rimbeault, Fatemeh Mohabatpour, Petros Papagerakis, Sean Maw, Xiongbiao Chen

Affiliations

  1. Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7N 5A9, Canada.
  2. School of Engineering, Icam Site de Paris-Sénart, 34 Points de Vue, 77127 Lieusaint, France.
  3. School of Engineering, Icam Site de Vendée, 28 Boulevard d'Angleterre, 85000 La Roche-sur-Yon, France.
  4. College of Dentistry, University of Saskatchewan, 105 Wiggins Road, Saskatoon, SK S7N 5E4, Canada.
  5. Graham School of Professional Development, 57 Campus Drive, Saskatoon, SK S7N 5A9, Canada.

PMID: 34449625 PMCID: PMC8395907 DOI: 10.3390/jfb12030045

Abstract

Three-dimensional (3D) bioprinting is an emerging fabrication technique to create 3D constructs with living cells. Notably, bioprinting bioinks are limited due to the mechanical weakness of natural biomaterials and the low bioactivity of synthetic peers. This paper presents the development of a natural bioink from chicken eggwhite and sodium alginate for bioprinting cell-laden patches to be used in endothelialized tissue engineering applications. Eggwhite was utilized for enhanced biological properties, while sodium alginate was used to improve bioink printability. The rheological properties of bioinks with varying amounts of sodium alginate were examined with the results illustrating that 2.0-3.0% (

Keywords: 3D bioprinting; albumin; eggwhite-based bioink; vascularization

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