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Lim CY, Kim H, Chung MS. Mori Cortex Radicis extract inhibits human norovirus surrogate in simulated digestive conditions. Food Sci Biotechnol. 2021;1-6doi: 10.1007/s10068-021-00958-0.
Lim, C. Y., Kim, H., & Chung, M. S. (2021). Mori Cortex Radicis extract inhibits human norovirus surrogate in simulated digestive conditions. Food science and biotechnology, 1-6. https://doi.org/10.1007/s10068-021-00958-0
Lim, Chae Yeon, et al. "Mori Cortex Radicis extract inhibits human norovirus surrogate in simulated digestive conditions." Food science and biotechnology vol. (2021): 1-6. doi: https://doi.org/10.1007/s10068-021-00958-0
Lim CY, Kim H, Chung MS. Mori Cortex Radicis extract inhibits human norovirus surrogate in simulated digestive conditions. Food Sci Biotechnol. 2021 Aug 29;1-6. doi: 10.1007/s10068-021-00958-0. Epub 2021 Aug 29. PMID: 34483697; PMCID: PMC8403467.
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Food Sci Biotechnol. 2021 Aug 29;1-6. doi: 10.1007/s10068-021-00958-0. Epub 2021 Aug 29.

Mori Cortex Radicis extract inhibits human norovirus surrogate in simulated digestive conditions.

Food science and biotechnology

Chae Yeon Lim, Hyojin Kim, Mi Sook Chung

Affiliations

  1. Department of Food and Nutrition, Duksung Women's University, Seoul, 01369 Korea.

PMID: 34483697 PMCID: PMC8403467 DOI: 10.1007/s10068-021-00958-0

Abstract

Norovirus is a major cause of acute gastroenteritis globally, resulting in enormous health and societal costs. In this study, the antiviral activities of Mori Cortex Radicis (MCR) extract and its bioactive flavonoids, morusin and kuwanon G, were tested against murine norovirus (MNV), a human norovirus surrogate, using plaque assay. The antiviral activity was confirmed in simulated digestive conditions, including simulated saliva fluid (SSF), simulated gastric fluid (SGF), and simulated intestinal fluid (SIF). Pre-treatment of MNV with MCR extract at 1000 µg/mL showed antiviral activity with a 1.1-log reduction. Morusin and kuwanon G also demonstrated a 1.0-log and 0.6-log reductions of MNV titers, respectively, at 100 µM. MCR extract at a concentration of 2 mg/mL in SSF, SGF, and SIF markedly reduced MNV titers by 1.8, 1.9, and 1.5 logs, respectively. Therefore, these data suggest that MCR extract can be used to control norovirus infectivity.

© The Korean Society of Food Science and Technology 2021.

Keywords: Kuwanon G; Mori Cortex Radicis; Morusin; Murine norovirus; Simulated digestive conditions

Conflict of interest statement

Conflict of interestNone of the authors of this study has any financial interest or conflict with industries or parties.

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