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Kabir A, Lotfi S, Farsi F, et al. Impact of body mass index on immunogenicity of hepatitis B vaccine in bariatric surgery candidates: A retrospective study. Diabetes Metab Syndr. 2021;15(5):102254doi: 10.1016/j.dsx.2021.102254.
Kabir, A., Lotfi, S., Farsi, F., & Pazouki, A. (2021). Impact of body mass index on immunogenicity of hepatitis B vaccine in bariatric surgery candidates: A retrospective study. Diabetes & metabolic syndrome, 15(5), 102254. https://doi.org/10.1016/j.dsx.2021.102254
Kabir, Ali, et al. "Impact of body mass index on immunogenicity of hepatitis B vaccine in bariatric surgery candidates: A retrospective study." Diabetes & metabolic syndrome vol. 15,5 (2021): 102254. doi: https://doi.org/10.1016/j.dsx.2021.102254
Kabir A, Lotfi S, Farsi F, Pazouki A. Impact of body mass index on immunogenicity of hepatitis B vaccine in bariatric surgery candidates: A retrospective study. Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102254. doi: 10.1016/j.dsx.2021.102254. Epub 2021 Aug 22. PMID: 34450550.
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Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102254. doi: 10.1016/j.dsx.2021.102254. Epub 2021 Aug 22.

Impact of body mass index on immunogenicity of hepatitis B vaccine in bariatric surgery candidates: A retrospective study.

Diabetes & metabolic syndrome

Ali Kabir, Samaneh Lotfi, Farnaz Farsi, Abdolreza Pazouki

Affiliations

  1. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].
  2. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
  3. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran; Center of Excellence for Minimally Invasive Surgery Training, Iran University of Medical Sciences, Tehran, Iran; Center of Excellence of European Branch of International Federation for Surgery of Obesity, Tehran, Iran. Electronic address: [email protected].

PMID: 34450550 DOI: 10.1016/j.dsx.2021.102254

Abstract

AIMS: Hepatitis B virus (HBV) immunization is regarded as the most effective method for the prevention of HBV infection. Various factors, including body mass index (BMI), may contribute to decreased immunization responses. This study aimed to investigate the relationship between BMI at the time of vaccination with anti-HBs levels over the following years.

METHODS: In this retrospective study, 790 vaccinated participants were recruited. Of these, individuals were selected whose hepatitis B antibody (HBsAb) information was available in 2017. The researchers contacted participants by phone to gather data regarding vaccination history, and weight at the time of vaccination. All data analysis was performed by SPSS.

RESULTS: This study included 165 eligible adults (28 males and 137 females). Among them, 79% participants were obese. Additionally, 46 (27.88%) and 119 (72.12%) had negative and positive HBsAb, respectively. There were no statistically significant differences seen across all characteristics, except for the number of HBV vaccinations between the positive and negative HBsAb groups. Multiple logistic regression also indicated no meaningful relationship between BMI and positive antibodies.

CONCLUSION: There was no relationship observed between BMI and immune response to HBV vaccine in bariatric candidates. Known risk factors (age, sex, diabetes, and the number of HBV vaccinations) were not independent predictors of the antibody response to the HBV vaccine.

Copyright © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Keywords: Body mass index; Hepatitis B antibodies; Hepatitis B vaccines

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

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