Display options
Cite
Franzo G, Menandro ML, Tucciarone CM, et al. Canine Circovirus in Foxes from Northern Italy: Where Did It All Begin?. Pathogens. 2021;10(8)doi: 10.3390/pathogens10081002.
Franzo, G., Menandro, M. L., Tucciarone, C. M., Barbierato, G., Crovato, L., Mondin, A., Libanora, M., Obber, F., Orusa, R., Robetto, S., Citterio, C., & Grassi, L. (2021). Canine Circovirus in Foxes from Northern Italy: Where Did It All Begin?. Pathogens (Basel, Switzerland), 10(8), . https://doi.org/10.3390/pathogens10081002
Franzo, Giovanni, et al. "Canine Circovirus in Foxes from Northern Italy: Where Did It All Begin?." Pathogens (Basel, Switzerland) vol. 10,8 (2021). doi: https://doi.org/10.3390/pathogens10081002
Franzo G, Menandro ML, Tucciarone CM, Barbierato G, Crovato L, Mondin A, Libanora M, Obber F, Orusa R, Robetto S, Citterio C, Grassi L. Canine Circovirus in Foxes from Northern Italy: Where Did It All Begin?. Pathogens. 2021 Aug 09;10(8). doi: 10.3390/pathogens10081002. PMID: 34451466; PMCID: PMC8400258.
Copy Download .nbib Format: NLM
Share it on

Pathogens. 2021 Aug 09;10(8). doi: 10.3390/pathogens10081002.

Canine Circovirus in Foxes from Northern Italy: Where Did It All Begin?.

Pathogens (Basel, Switzerland)

Giovanni Franzo, Maria Luisa Menandro, Claudia Maria Tucciarone, Giacomo Barbierato, Lorenzo Crovato, Alessandra Mondin, Martina Libanora, Federica Obber, Riccardo Orusa, Serena Robetto, Carlo Citterio, Laura Grassi

Affiliations

  1. Department of Animal Medicine, Production and Health (MAPS), University of Padua, 35020 Legnaro, Italy.
  2. O.U. of Ecopathology, SCT2 Belluno, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), 32100 Belluno, Italy.
  3. S.C. Valle d.'Aosta-National Reference Centre Wildlife Diseases, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta (IZS PLV)-Ce.R.M.A.S., 11020 Quart, AO, Italy.

PMID: 34451466 PMCID: PMC8400258 DOI: 10.3390/pathogens10081002

Abstract

Canine circovirus (CanineCV) is a recently identified virus affecting both domestic and wild carnivores, including foxes, sometimes in presence of severe clinical signs. Its circulation in wild animals can thus represent a potential threat for endangered species conservation and an infection source for dogs. Nevertheless, no data were available on its circulation in the Alps region of Northern Italy. In the present study, samples collected from 186 foxes in the period 2009-2020 from Valle d'Aosta and Veneto regions were tested using a real-time PCR assay, demonstrating a viral circulation of approximatively 2-5%, depending on the considered regions. Two complete or almost complete genome sequences were obtained, highlighting that the detected strains were part of a so defined "fox only" clade, which suggests that, despite common contact opportunities, Alps foxes are not involved in frequent transmission events to domestic dogs. Such genetic isolation could be at least partially attributed to some sort of independent evolution occurred in the foxes, leading to species barrier. Additionally, CanineCV strains in foxes from Italy were unexpectedly related to those previously identified in foxes from the United Kingdom and Scandinavian area. Combining the history of fox distribution in Europe since the last glacial maximum (LGM) with the viral history allowed us to speculate a long-standing coexistence between European canine circovirus and this host, justifying the peculiar geographic distribution and evolutionary paths of the fox infecting clade.

Keywords: CanineCV; Italy; evolution; fox; history; phylogenesis

References

  1. Vet Pathol. 2016 Nov;53(6):1204-1209 - PubMed
  2. Infect Ecol Epidemiol. 2015 Nov 27;5:30048 - PubMed
  3. Nat Methods. 2012 Jul 30;9(8):772 - PubMed
  4. J Virol. 2012 Jun;86(12):7018 - PubMed
  5. PLoS One. 2014 Aug 22;9(8):e105909 - PubMed
  6. Virus Evol. 2015 May 26;1(1):vev003 - PubMed
  7. Epidemiol Infect. 1998 Oct;121(2):433-40 - PubMed
  8. J Wildl Dis. 2019 Jan;55(1):3-43 - PubMed
  9. Emerg Infect Dis. 2013 Apr;19(4):534-41 - PubMed
  10. Proc Biol Sci. 2014 Jul 7;281(1786): - PubMed
  11. Mol Biol Evol. 2015 Jan;32(1):268-74 - PubMed
  12. J Virol. 2016 Jul 27;90(16):7184-95 - PubMed
  13. PLoS One. 2019 Mar 12;14(3):e0213515 - PubMed
  14. J Wildl Dis. 2020 Jan;56(1):239-242 - PubMed
  15. Emerg Infect Dis. 2015 Jul;21(7):1205-8 - PubMed
  16. Virology. 2016 Mar;490:69-74 - PubMed
  17. Vet Parasitol. 2015 Sep 30;213(1-2):12-23 - PubMed
  18. Virus Evol. 2018 Jun 08;4(1):vey016 - PubMed
  19. Arch Virol. 2021 Jun;166(6):1723-1728 - PubMed
  20. Vet Microbiol. 1999 Sep 1;69(1-2):47-50 - PubMed
  21. Mol Biol Evol. 2013 Apr;30(4):772-80 - PubMed
  22. Mol Biol Evol. 2013 Feb;30(2):239-43 - PubMed
  23. Vet Rec. 2017 Jun 3;180(22):542 - PubMed
  24. BMC Vet Res. 2016 Jun 17;12(1):116 - PubMed
  25. Mol Phylogenet Evol. 2019 Oct;139:106520 - PubMed
  26. Transbound Emerg Dis. 2019 Jul;66(4):1548-1557 - PubMed
  27. J Virol. 2010 Dec;84(23):12458-62 - PubMed
  28. Front Vet Sci. 2019 Sep 19;6:319 - PubMed
  29. Nat Rev Genet. 2008 Apr;9(4):267-76 - PubMed
  30. Mol Ecol. 2011 Aug;20(15):3087-101 - PubMed
  31. Curr Opin Virol. 2011 Oct;1(4):304-9 - PubMed
  32. Transbound Emerg Dis. 2021 May;68(3):1283-1293 - PubMed
  33. Mol Phylogenet Evol. 2016 Jul;100:281-291 - PubMed

Publication Types