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Story D, Gallien J, Al-Gharaibeh A, et al. Housing R6/2 Mice with Wild-Type Littermates Increases Lifespan. J Huntingtons Dis. 2021;10(4):455-458doi: 10.3233/JHD-210474.
Story, D., Gallien, J., Al-Gharaibeh, A., Sandstrom, M., Rossignol, J., & Dunbar, G. L. (2021). Housing R6/2 Mice with Wild-Type Littermates Increases Lifespan. Journal of Huntington's disease, 10(4), 455-458. https://doi.org/10.3233/JHD-210474
Story, Darren, et al. "Housing R6/2 Mice with Wild-Type Littermates Increases Lifespan." Journal of Huntington's disease vol. 10,4 (2021): 455-458. doi: https://doi.org/10.3233/JHD-210474
Story D, Gallien J, Al-Gharaibeh A, Sandstrom M, Rossignol J, Dunbar GL. Housing R6/2 Mice with Wild-Type Littermates Increases Lifespan. J Huntingtons Dis. 2021;10(4):455-458. doi: 10.3233/JHD-210474. PMID: 34511507.
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J Huntingtons Dis. 2021;10(4):455-458. doi: 10.3233/JHD-210474.

Housing R6/2 Mice with Wild-Type Littermates Increases Lifespan.

Journal of Huntington's disease

Darren Story, John Gallien, Abeer Al-Gharaibeh, Michael Sandstrom, Julien Rossignol, Gary L Dunbar

Affiliations

  1. Field Neurosciences Institute for Restorative Neurology, Central Michigan University, Mount Pleasant, MI, USA.
  2. Department of Psychology, Central Michigan University, Mount Pleasant, MI, USA.
  3. Program in Neuroscience, Central Michigan University, Mount Pleasant, MI, USA.
  4. College of Medicine, Central Michigan University, Mount Pleasant, MI, USA.
  5. Field Neurosciences Institute, St. Mary's of Michigan, Saginaw, MI, USA.

PMID: 34511507 DOI: 10.3233/JHD-210474

Abstract

The R6/2 murine model of Huntington's disease (HD) is extensively used in HD research. The current study replicates and extends previous work assessing the impact of housing R6/2 mice with healthy wild-type (WT) littermates on disease progression. The current study extends the previous finding by including male cohorts and the use of a standard diet and water regimen, as opposed to the enhanced diet used in the previous study. This study found that the inclusion of healthy wild-type (WT) littermates, alone, improved survivabilty in R6/2 mice, but did not have a significant impact on weight loss.

Keywords: Huntington’s disease; R6/2; environmental enrichment; housing; survivability

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