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Front Cell Dev Biol. 2021 Aug 26;9:736738. doi: 10.3389/fcell.2021.736738. eCollection 2021.

Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth.

Frontiers in cell and developmental biology

Jiarui Zhang, Ruosi Chen, Lihong Wen, Zhexiang Fan, Yilong Guo, Zhiqi Hu, Yong Miao

Affiliations

  1. Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

PMID: 34513851 PMCID: PMC8427189 DOI: 10.3389/fcell.2021.736738

Abstract

Clinical observation and experimental studies have long suggested that the perifollicular nerves have nutritional and regulatory effects on the growth, development, and physiological cycle of hair follicles (HFs), even though the concrete mechanism remains obscure. Recently, with the progress of immunohistochemistry and molecular biology techniques, more innovation has been made in the study of the follicular sympathetic nerves and its nerve-effect factor norepinephrine affecting hair follicle stem cells. This review highlights the progress in the regulation of the sympathetic nervous system toward the growth of HFs.

Copyright © 2021 Zhang, Chen, Wen, Fan, Guo, Hu and Miao.

Keywords: hair follicle stem cells; hair follicles; hair growth; norepinephrine; sympathetic nerves

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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