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Jaramillo V, Jendoubi J, Maric A, et al. Thalamic Influence on Slow Wave Slope Renormalization During Sleep. Ann Neurol. 2021;90(5):821-833doi: 10.1002/ana.26217.
Jaramillo, V., Jendoubi, J., Maric, A., Mensen, A., Heyse, N. C., Eberhard-Moscicka, A. K., Wiest, R., Bassetti, C. L. A., & Huber, R. (2021). Thalamic Influence on Slow Wave Slope Renormalization During Sleep. Annals of neurology, 90(5), 821-833. https://doi.org/10.1002/ana.26217
Jaramillo, Valeria, et al. "Thalamic Influence on Slow Wave Slope Renormalization During Sleep." Annals of neurology vol. 90,5 (2021): 821-833. doi: https://doi.org/10.1002/ana.26217
Jaramillo V, Jendoubi J, Maric A, Mensen A, Heyse NC, Eberhard-Moscicka AK, Wiest R, Bassetti CLA, Huber R. Thalamic Influence on Slow Wave Slope Renormalization During Sleep. Ann Neurol. 2021 Nov;90(5):821-833. doi: 10.1002/ana.26217. Epub 2021 Sep 30. PMID: 34516002.
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Ann Neurol. 2021 Nov;90(5):821-833. doi: 10.1002/ana.26217. Epub 2021 Sep 30.

Thalamic Influence on Slow Wave Slope Renormalization During Sleep.

Annals of neurology

Valeria Jaramillo, Jasmine Jendoubi, Angelina Maric, Armand Mensen, Natalie C Heyse, Aleksandra K Eberhard-Moscicka, Roland Wiest, Claudio L A Bassetti, Reto Huber

Affiliations

  1. Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich.
  2. Child Development Center, University Children's Hospital Zurich, University of Zurich, Zurich.
  3. Sleep-Wake-Epilepsy Center, Department of Neurology, University Hospital Bern, University of Bern, Bern, Switzerland.
  4. Center for Experimental Neurology, Department of Neurology, University Hospital Bern, University of Bern, Bern, Switzerland.
  5. Department of Neurology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  6. Perception and Eye Movement Laboratory, Departments of Neurology and Biomedical Research, University Hospital Bern, University of Bern, Bern, Switzerland.
  7. Department of Neuroradiology, University Hospital Bern, University of Bern, Bern, Switzerland.
  8. Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich.

PMID: 34516002 DOI: 10.1002/ana.26217

Abstract

OBJECTIVE: Slow waves are thought to mediate an overall reduction in synaptic strength during sleep. The specific contribution of the thalamus to this so-called synaptic renormalization is unknown. Thalamic stroke is associated with daytime sleepiness, along with changes to sleep electroencephalography and cognition, making it a unique "experiment of nature" to assess the relationship between sleep rhythms, synaptic renormalization, and daytime functions.

METHODS: Sleep was studied by polysomnography and high-density electroencephalography over 17 nights in patients with thalamic (n = 12) and 15 nights in patients with extrathalamic (n = 11) stroke. Sleep electroencephalographic overnight slow wave slope changes and their relationship with subjective daytime sleepiness, cognition, and other functional tests were assessed.

RESULTS: Thalamic and extrathalamic patients did not differ in terms of age, sleep duration, or apnea-hypopnea index. Conversely, overnight slope changes were reduced in a large cluster of electrodes in thalamic compared to extrathalamic stroke patients. This reduction was related to increased daytime sleepiness. No significant differences were found in other functional tests between the 2 groups.

INTERPRETATION: In patients with thalamic stroke, a reduction in overnight slow wave slope change and increased daytime sleepiness was found. Sleep- and wake-centered mechanisms for this relationship are discussed. Overall, this study suggests a central role of the thalamus in synaptic renormalization. ANN NEUROL 2021;90:821-833.

© 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

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