Display options
Share it on

Phys Chem Chem Phys. 2021 Sep 29;23(37):20945-20956. doi: 10.1039/d1cp03237b.

Probing the formation of isolated cyclo-FF peptide clusters by far-infrared action spectroscopy.

Physical chemistry chemical physics : PCCP

Sjors Bakels, Iuliia Stroganova, Anouk M Rijs

Affiliations

  1. Radboud University, FELIX Laboratory, Institute for Molecules and Materials, Toernooiveld 7, 6525 ED Nijmegen, The Netherlands.
  2. Division of BioAnalytical Chemistry, AIMMS Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HV, Amsterdam, The Netherlands. [email protected].

PMID: 34545387 DOI: 10.1039/d1cp03237b

Abstract

Small cyclic peptides containing phenylalanine residues are prone to aggregate in the gas phase into highly hydrophobic chains. A combination of laser desorption, mass spectrometry and conformational selective IR-UV action spectroscopy allows us to obtain detailed structural insights into the formation processes of the cyclic L-phenylalanyl-L-phenylalanine dipeptide (named cyclo-FF) aggregates. The rigid properties of cyclo-FF result in highly resolved IR spectra for the smaller clusters (

Publication Types