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Koman-Wierdak E, Róg J, Brzozowska A, et al. Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder. J Clin Med. 2021;10(18)doi: 10.3390/jcm10184131.
Koman-Wierdak, E., Róg, J., Brzozowska, A., Toro, M. D., Bonfiglio, V., Załuska-Ogryzek, K., Karakuła-Juchnowicz, H., Rejdak, R., & Nowomiejska, K. (2021). Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder. Journal of clinical medicine, 10(18), . https://doi.org/10.3390/jcm10184131
Koman-Wierdak, Edyta, et al. "Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder." Journal of clinical medicine vol. 10,18 (2021). doi: https://doi.org/10.3390/jcm10184131
Koman-Wierdak E, Róg J, Brzozowska A, Toro MD, Bonfiglio V, Załuska-Ogryzek K, Karakuła-Juchnowicz H, Rejdak R, Nowomiejska K. Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder. J Clin Med. 2021 Sep 13;10(18). doi: 10.3390/jcm10184131. PMID: 34575242; PMCID: PMC8472507.
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J Clin Med. 2021 Sep 13;10(18). doi: 10.3390/jcm10184131.

Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder.

Journal of clinical medicine

Edyta Koman-Wierdak, Joanna Róg, Agnieszka Brzozowska, Mario Damiano Toro, Vincenza Bonfiglio, Katarzyna Załuska-Ogryzek, Hanna Karakuła-Juchnowicz, Robert Rejdak, Katarzyna Nowomiejska

Affiliations

  1. Department of General Ophthalmology, Medical University of Lublin, 20-079 Lublin, Poland.
  2. Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-079 Lublin, Poland.
  3. Department of Mathematics and Medical Biostatistics, Medical University of Lublin, 20-079 Lublin, Poland.
  4. Department of Ophthalmology, University of Zurich, 8091 Zurich, Switzerland.
  5. Department of Experimental Biomedicine and Clinical Neuroscience, Ophthalmology Section, University of Palermo, 90127 Palermo, Italy.
  6. Department of Pathophysiology, Medical University of Lublin, 20-079 Lublin, Poland.

PMID: 34575242 PMCID: PMC8472507 DOI: 10.3390/jcm10184131

Abstract

PURPOSE: To measure RNFL and vasculature around the optic disc and in the macula in patients with schizophrenia (SZ) and bipolar disorder (BD) using optical coherence tomography angiography (OCTA).

METHODS: 24 eyes of patients with SZ and 16 eyes of patients with BD as well as 30 eyes of healthy subjects were examined with OCTA. The radiant peripapillary capillary (RPC) density and RNFL thickness were measured in the peripapillary area. Moreover, macular thickness and vessel density were measured in both superficial and deep layers.

RESULTS: Significantly decreased values of vessel density in the macular deep vascular complex were found in the eyes of patients with SZ, compared to BD and the control group. The macular thickness in the whole vascular complex and in the fovea was significantly lower in SZ and BD group than in the control group. The radiant peripapillary vascular density and RNFL thickness were similar across groups.

CONCLUSIONS: The retinal microvascular dysfunction occurs in the macula in patients with SZ and BD, but not around optic disc. OCTA can become an essential additional diagnostic tool in detection of psychiatric disorders.

Keywords: OCTA; bipolar disorder; microvascular dysfunction; schizophrenia

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