Environ Sci Pollut Res Int. 2021 Sep 21; doi: 10.1007/s11356-021-16352-6. Epub 2021 Sep 21.

Bioconcentration and toxicological impacts of fipronil and 2,4-D commercial formulations (single and in mixture) in the tropical fish, Danio rerio.

Environmental science and pollution research international

Natália Prudêncio Viana, Laís Conceição Menezes da Silva, Natália Portruneli, Michelly Pereira Soares, Israel Luz Cardoso, Rocío Inés Bonansea, Bianca Veloso Goulart, Cassiana Carolina Montagner, Evaldo Luiz Gaeta Espíndola, Daniel Alberto Wunderlin, Marisa Narciso Fernandes

PMID: 34546525 DOI: 10.1007/s11356-021-16352-6

Abstract

The insecticide fipronil and the herbicide 2,4-D are the most applied pesticides in sugarcane crops leading to aquatic contamination. The whole-body bioconcentration of fipronil and 2,4-D, single and in mixture, was evaluated in Danio rerio after 96-h exposure. The activities of catalase (CAT) and glutathione S-transferase(GST) in whole body and in the gills and the acetylcholinesterase (AChE) in muscle were determined. The gill histopathology and the morphology of the pavement (PVC) and the mitochondria-rich(MRC) cells at gill surface were analyzed. Bioconcentration occurred after exposure to fipronil (2.69 L kg

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords: Acetylcholinesterase; Bioconcentration; Catalase; Glutathione S-transferase; Histopathology; Mitochondria-rich cells

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