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Dubromel A, Caffin AG, Hacard F, et al. Preparations of exploration of immediate hypersensitivity to antineoplastic agents: An oncology pharmacy perspective. J Oncol Pharm Pract. 2021;10781552211035695doi: 10.1177/10781552211035695.
Dubromel, A., Caffin, A. G., Hacard, F., Vantard, N., Baudouin, A., Herledan, C., Larbre, V., Schwiertz, V., Nosbaum, A., Pralong, P., Nicolas, J. F., Berard, F., Rioufol, C., & Ranchon, F. (2021). Preparations of exploration of immediate hypersensitivity to antineoplastic agents: An oncology pharmacy perspective. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 10781552211035695. https://doi.org/10.1177/10781552211035695
Dubromel, Amélie, et al. "Preparations of exploration of immediate hypersensitivity to antineoplastic agents: An oncology pharmacy perspective." Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners vol. (2021): 10781552211035695. doi: https://doi.org/10.1177/10781552211035695
Dubromel A, Caffin AG, Hacard F, Vantard N, Baudouin A, Herledan C, Larbre V, Schwiertz V, Nosbaum A, Pralong P, Nicolas JF, Berard F, Rioufol C, Ranchon F. Preparations of exploration of immediate hypersensitivity to antineoplastic agents: An oncology pharmacy perspective. J Oncol Pharm Pract. 2021 Sep 21;10781552211035695. doi: 10.1177/10781552211035695. Epub 2021 Sep 21. PMID: 34546819.
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J Oncol Pharm Pract. 2021 Sep 21;10781552211035695. doi: 10.1177/10781552211035695. Epub 2021 Sep 21.

Preparations of exploration of immediate hypersensitivity to antineoplastic agents: An oncology pharmacy perspective.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Amélie Dubromel, Anne-Gaëlle Caffin, Florence Hacard, Nicolas Vantard, Amandine Baudouin, Chloé Herledan, Virginie Larbre, Vérane Schwiertz, Audrey Nosbaum, Pauline Pralong, Jean-François Nicolas, Frédéric Berard, Catherine Rioufol, Florence Ranchon

Affiliations

  1. Groupement Hospitalier Sud, Clinical Oncology Pharmacy Department, 26900Hospices Civils de Lyon, France.
  2. Groupement Hospitalier Sud, Allergy and Clinical Immunology Department, 26900Hospices Civils de Lyon, France.
  3. 27098Université Lyon 1, EA 3738, Centre d'Innovation en Cancérologie de Lyon, France.
  4. Université Lyon 1, Inserm, U111 CNRS, UMR5308, ENS de Lyon, Lyon, France.

PMID: 34546819 DOI: 10.1177/10781552211035695

Abstract

BACKGROUND: Cancer patients are being exposed to antineoplastic drugs more frequently and for longer periods, resulting in a higher risk of hypersensitivity reactions. The aim of this study was to assess the pharmaceutical time and direct cost of drug allergy explorations following immediate hypersensitivity reactions to antineoplastic agents.

METHODS: A micro-costing method was used to collect data on consumption of human and material resources for allergy exploration preparations. The monetisation was carried out on the basis of prices and hourly wage costs applied in 2018. The number and type of allergy explorations prepared by the pharmacy as well as nature of antineoplastic drugs tested, and the number of culprit drugs reintroductions were collected.

RESULTS: Almost 1.5 h is required to realise allergy tests for one patient including pharmacist time for prescription analysis and pharmacy technician's time for tests preparation. The mean manufacturing cost of these tests is estimated at €62.87 (€57.82-65.49) per culprit drug for one patient. Programming patients according to culprit drugs tested allows rationalising healthcare provider time and increasing efficiency. From January 2010 to December 2018, 277 patients were tested and 490 allergy explorations were performed, corresponding to more than 5000 preparations. Mostly, the culprit drug could be reintroduced (

CONCLUSION: Management of hypersensitivity reactions is constantly progressing, as it contributes to improving patient care in oncology. This activity is time-consuming for the pharmacy team but allows patients with previous hypersensitivity reaction to continue effective treatment.

Keywords: Hypersensitivity reaction; chemotherapy; desensitisation; monoclonal antibodies; pharmacist; skin tests

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