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Carmona-Rivera C, O'Neil LJ, Patino-Martinez E, et al. Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages. J Invest Dermatol. 2021;doi: 10.1016/j.jid.2021.07.187.
Carmona-Rivera, C., O'Neil, L. J., Patino-Martinez, E., Shipman, W. D., Zhu, C., Li, Q. Z., Kerns, M. L., Barnes, L. A., Caffrey, J. A., Kang, S., Kaplan, M. J., Okoye, G. A., & Byrd, A. S. (2021). Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages. The Journal of investigative dermatology, . https://doi.org/10.1016/j.jid.2021.07.187
Carmona-Rivera, Carmelo, et al. "Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages." The Journal of investigative dermatology vol. (2021). doi: https://doi.org/10.1016/j.jid.2021.07.187
Carmona-Rivera C, O'Neil LJ, Patino-Martinez E, Shipman WD, Zhu C, Li QZ, Kerns ML, Barnes LA, Caffrey JA, Kang S, Kaplan MJ, Okoye GA, Byrd AS. Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages. J Invest Dermatol. 2021 Oct 01; doi: 10.1016/j.jid.2021.07.187. Epub 2021 Oct 01. PMID: 34606886.
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J Invest Dermatol. 2021 Oct 01; doi: 10.1016/j.jid.2021.07.187. Epub 2021 Oct 01.

Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages.

The Journal of investigative dermatology

Carmelo Carmona-Rivera, Liam J O'Neil, Eduardo Patino-Martinez, William D Shipman, Chengsong Zhu, Quan-Zhen Li, Michelle L Kerns, Leandra A Barnes, Julie A Caffrey, Sewon Kang, Mariana J Kaplan, Ginette A Okoye, Angel S Byrd

Affiliations

  1. Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  2. Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
  3. Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, New York, USA.
  4. Microarray Core Facility, Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  5. Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  6. Department of Dermatology, Stanford Univeristy School of Medicine, Stanford, California, USA.
  7. Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  8. Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Dermatology, Howard University College of Medicine, Washington, District of Columbia, USA.
  9. Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Dermatology, Howard University College of Medicine, Washington, District of Columbia, USA. Electronic address: [email protected].

PMID: 34606886 DOI: 10.1016/j.jid.2021.07.187

Abstract

Hidradenitis suppurativa (HS), also known as acne inversa, is a debilitating inflammatory skin disorder that is characterized by nodules that lead to the development of connected tunnels and scars as it progresses from Hurley stages I to III. HS has been associated with several autoimmune diseases, including inflammatory bowel disease and spondyloarthritis. We previously reported dysregulation of humoral immune responses in HS, characterized by elevated serum total IgG, B-cell activation, and antibodies recognizing citrullinated proteins. In this study, we characterized IgG autoreactivity in HS sera and lesional skin compared with those in normal healthy controls using an array-based high-throughput autoantibody screening. The Cy3-labeled anti-human assay showed the presence of autoantibodies against nuclear antigens, cytokines, cytoplasmic proteins, extracellular matrix proteins, neutrophil proteins, and citrullinated antigens. Most of these autoantibodies were significantly elevated in stages II‒III in HS sera and stage III in HS skin lesions compared with those of healthy controls. Furthermore, immune complexes containing both native and citrullinated versions of antigens can activate M1 and M2 macrophages to release proinflammatory cytokines such as TNF-α, IL-8, IL-6, and IL-12. Taken together, the identification of specific IgG autoantibodies that recognize circulating and tissue antigens in HS suggests an autoimmune mechanism and uncovers putative therapeutic targets.

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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