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Anderson TN, Schreiber MA, Rowell SE. Viscoelastic Testing in Traumatic Brain Injury: Key Research Insights. Transfus Med Rev. 2021;35(4):108-112doi: 10.1016/j.tmrv.2021.08.002.
Anderson, T. N., Schreiber, M. A., & Rowell, S. E. (2021). Viscoelastic Testing in Traumatic Brain Injury: Key Research Insights. Transfusion medicine reviews, 35(4), 108-112. https://doi.org/10.1016/j.tmrv.2021.08.002
Anderson, Taylor N, et al. "Viscoelastic Testing in Traumatic Brain Injury: Key Research Insights." Transfusion medicine reviews vol. 35,4 (2021): 108-112. doi: https://doi.org/10.1016/j.tmrv.2021.08.002
Anderson TN, Schreiber MA, Rowell SE. Viscoelastic Testing in Traumatic Brain Injury: Key Research Insights. Transfus Med Rev. 2021 Oct;35(4):108-112. doi: 10.1016/j.tmrv.2021.08.002. Epub 2021 Sep 04. PMID: 34607730.
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Transfus Med Rev. 2021 Oct;35(4):108-112. doi: 10.1016/j.tmrv.2021.08.002. Epub 2021 Sep 04.

Viscoelastic Testing in Traumatic Brain Injury: Key Research Insights.

Transfusion medicine reviews

Taylor N Anderson, Martin A Schreiber, Susan E Rowell

Affiliations

  1. Department of Surgery, Stanford University, Stanford, California, USA. Electronic address: [email protected].
  2. Professor of Surgery, Division of Trauma, Critical Care & Acute Care Surgery, Oregon Health & Science University, USA.
  3. Professor of Surgery, Division of Trauma Surgery and Critical Care Medicine, University of Chicago, USA.

PMID: 34607730 DOI: 10.1016/j.tmrv.2021.08.002

Abstract

The role of viscoelastic testing in the evaluation and management of traumatic brain injury (TBI) remains a subject of ongoing exploration. This review highlights four key publications that provide significant insights into this subject. Holcomb et al. provided early evidence of the relationship between thromboelastography (TEG) and conventional coagulation tests (CCTs). Later, Samuels et al. used TEG to identify a unique coagulopathy phenotype in TBI characterized by a notable absence of fibrinolytic abnormalities. Dixon et al. built upon these findings by exploring the application of TEG in the context of antifibrinolytic administration, noting a similar lack of effect on LY30. Finally, Guillotte et al. demonstrated the utility of TEG-PM in assessing platelet dysfunction in TBI. While these studies provide key early support for the utility of viscoelastic testing in the TBI, further exploration is needed to define evidence-based guidelines for clinical application.

Copyright © 2021. Published by Elsevier Inc.

Keywords: Blood coagulation; Blood transfusion; Brain injuries; Craniocerebral trauma; Fibrinolysis; Platelet transfusion; Resuscitation; Thromboelastography; Tranexamic acid; Traumatic

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