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Trivillin VA, Langle YV, Palmieri MA, et al. Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model. Br J Radiol. 2021;94(1128):20210593doi: 10.1259/bjr.20210593.
Trivillin, V. A., Langle, Y. V., Palmieri, M. A., Pozzi, E. C. C., Thorp, S. I., Benitez Frydryk, D. N., Garabalino, M. A., Monti Hughes, A., Curotto, P. M., Colombo, L. L., Santa Cruz, I. S., Ramos, P. S., Itoiz, M. E., Argüelles, C., Eiján, A. M., & Schwint, A. E. (2021). Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model. The British journal of radiology, 94(1128), 20210593. https://doi.org/10.1259/bjr.20210593
Trivillin, Verónica A, et al. "Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model." The British journal of radiology vol. 94,1128 (2021): 20210593. doi: https://doi.org/10.1259/bjr.20210593
Trivillin VA, Langle YV, Palmieri MA, Pozzi ECC, Thorp SI, Benitez Frydryk DN, Garabalino MA, Monti Hughes A, Curotto PM, Colombo LL, Santa Cruz IS, Ramos PS, Itoiz ME, Argüelles C, Eiján AM, Schwint AE. Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model. Br J Radiol. 2021 Dec;94(1128):20210593. doi: 10.1259/bjr.20210593. Epub 2021 Sep 14. PMID: 34520668; PMCID: PMC8631031.
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Br J Radiol. 2021 Dec;94(1128):20210593. doi: 10.1259/bjr.20210593. Epub 2021 Sep 14.

Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model.

The British journal of radiology

Verónica A Trivillin, Yanina V Langle, Mónica A Palmieri, Emiliano C C Pozzi, Silvia I Thorp, Debora N Benitez Frydryk, Marcela A Garabalino, Andrea Monti Hughes, Paula M Curotto, Lucas L Colombo, Iara S Santa Cruz, Paula S Ramos, María E Itoiz, Claudia Argüelles, Ana M Eiján, Amanda E Schwint

Affiliations

  1. Comisión Nacional de Energía Atómica (CNEA), Buenos Aires, Argentina.
  2. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
  3. Universidad de Buenos Aires, Instituto de Oncología Ángel H. Roffo, Área Investigación, Buenos Aires, Argentina.
  4. Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
  5. Facultad de Odontología, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
  6. Instituto Nacional de Producción de Biológicos, ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina.

PMID: 34520668 PMCID: PMC8631031 DOI: 10.1259/bjr.20210593

Abstract

OBJECTIVE: The aim of the present study was to evaluate the local and regional therapeutic efficacy and abscopal effect of BNCT mediated by boronophenyl-alanine, combined with Bacillus Calmette-Guerin (BCG) as an immunotherapy agent in this model.

METHODS: The local effect of treatment was evaluated in terms of tumor response in the irradiated tumor-bearing right hind flank. Metastatic spread to tumor-draining lymph nodes was analyzed as an indicator of regional effect. The abscopal effect of treatment was assessed as tumor growth inhibition in the contralateral (non-irradiated) left hind flank inoculated with tumor cells 2 weeks post-irradiation. The experimental groups BNCT, BNCT + BCG, BCG, Beam only (BO), BO +BCG, SHAM (tumor-bearing, no treatment, same manipulation) were studied.

RESULTS: BNCT and BNCT + BCG induced a highly significant local anti-tumor response, whereas BCG alone induced a weak local effect. BCG and BNCT + BCG induced a significant abscopal effect in the contralateral non-irradiated leg. The BNCT + BCG group showed significantly less metastatic spread to tumor-draining lymph nodes

CONCLUSION: This study suggests that BNCT + BCG-immunotherapy would induce local, regional and abscopal effects in tumor-bearing animals. BNCT would be the main effector of the local anti-tumor effect whereas BCG would be the main effector of the abscopal effect.

ADVANCES IN KNOWLEDGE: Although the local effect of BNCT has been widely evidenced, this is the first study to show the local, regional and abscopal effects of BNCT combined with immunotherapy, contributing to comprehensive cancer treatment with combined therapies.

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