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Malinee M, Pandian GN, Sugiyama H. Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model. Cell Chem Biol. 2021;doi: 10.1016/j.chembiol.2021.08.001.
Malinee, M., Pandian, G. N., & Sugiyama, H. (2021). Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model. Cell chemical biology, . https://doi.org/10.1016/j.chembiol.2021.08.001
Malinee, Madhu, et al. "Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model." Cell chemical biology vol. (2021). doi: https://doi.org/10.1016/j.chembiol.2021.08.001
Malinee M, Pandian GN, Sugiyama H. Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model. Cell Chem Biol. 2021 Sep 11; doi: 10.1016/j.chembiol.2021.08.001. Epub 2021 Sep 11. PMID: 34520746.
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Cell Chem Biol. 2021 Sep 11; doi: 10.1016/j.chembiol.2021.08.001. Epub 2021 Sep 11.

Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model.

Cell chemical biology

Madhu Malinee, Ganesh Namasivayam Pandian, Hiroshi Sugiyama

Affiliations

  1. Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  2. Institute of Integrated Cell Material Sciences (iCeMS), Kyoto University of Advanced Study, Kyoto, Japan. Electronic address: [email protected].
  3. Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, Japan. Electronic address: [email protected].

PMID: 34520746 DOI: 10.1016/j.chembiol.2021.08.001

Abstract

Considering the potential of combinatorial therapies in overcoming existing limitations of cancer immunotherapy, there is an increasing need to identify small-molecule modulators of immune cells capable of augmenting the effect of programmed cell death protein 1 (PD-1) blockade, leading to better cancer treatment. Although epigenetic drugs showed potential in combination therapy, the lack of sequence specificity is a major concern. Here, we identify and develop a DNA-based epigenetic activator with tri-arginine vector called EnPGC-1 that can trigger the targeted induction of the peroxisome proliferator-activated receptor-gamma coactivator 1 alpha/beta (PGC-1α/β), a regulator of mitochondrial biogenesis. EnPGC-1 enhances mitochondrial activation, energy metabolism, proliferation of CD8

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: PD-1; T-cell activation; cancer immunotherapy; combination therapy; epigenetic activator; mitochondrial biogenesis; oxidative phosphorylation; pyrrole-imidazole polyamide; therapeutic gene modulation

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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