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Miranda GDS, de Lima TAL, Costermani HO, et al. Breastfeeding undernutrition changes iBAT-involved thermogenesis protein expression and leads to a lean phenotype in adult rat offspring. J Nutr Biochem. 2021;99:108857doi: 10.1016/j.jnutbio.2021.108857.
Miranda, G. D. S., de Lima, T. A. L., Costermani, H. O., Ricken, C. L. R. D. S., Parrela, J. P. S. S., Membrive, B. L. A., de Almeida, R. E., Facchi, J. C., de Oliveira, L. R., Miranda, R. A., de Moura, E. G., Lisboa, P. C., & de Oliveira, J. C. (2022). Breastfeeding undernutrition changes iBAT-involved thermogenesis protein expression and leads to a lean phenotype in adult rat offspring. The Journal of nutritional biochemistry, 99108857. https://doi.org/10.1016/j.jnutbio.2021.108857
Miranda, Ginislene Dias Souza, et al. "Breastfeeding undernutrition changes iBAT-involved thermogenesis protein expression and leads to a lean phenotype in adult rat offspring." The Journal of nutritional biochemistry vol. 99 (2022): 108857. doi: https://doi.org/10.1016/j.jnutbio.2021.108857
Miranda GDS, de Lima TAL, Costermani HO, Ricken CLRDS, Parrela JPSS, Membrive BLA, de Almeida RE, Facchi JC, de Oliveira LR, Miranda RA, de Moura EG, Lisboa PC, de Oliveira JC. Breastfeeding undernutrition changes iBAT-involved thermogenesis protein expression and leads to a lean phenotype in adult rat offspring. J Nutr Biochem. 2022 Jan;99:108857. doi: 10.1016/j.jnutbio.2021.108857. Epub 2021 Sep 11. PMID: 34520852.
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J Nutr Biochem. 2022 Jan;99:108857. doi: 10.1016/j.jnutbio.2021.108857. Epub 2021 Sep 11.

Breastfeeding undernutrition changes iBAT-involved thermogenesis protein expression and leads to a lean phenotype in adult rat offspring.

The Journal of nutritional biochemistry

Ginislene Dias Souza Miranda, Thalyne Aparecida Leite de Lima, Hercules de Oliveira Costermani, Camila Luiza Rodrigues Dos Santos Ricken, Jocemara Patrícia Silva de Souza Parrela, Bárbara Letícia Antonio Membrive, Raul Evangelista de Almeida, Júlia Cristina Facchi, Lucas Ryba de Oliveira, Rosiane Aparecida Miranda, Egberto Gaspar de Moura, Patrícia Cristina Lisboa, Júlio Cezar de Oliveira

Affiliations

  1. Research Group on Perinatal Programming of Metabolic Diseases: DOHaD paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, MT, Brazil.
  2. Laboratory of Endocrine Physiology, Department of Physiological Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  3. Research Group on Perinatal Programming of Metabolic Diseases: DOHaD paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, MT, Brazil. Electronic address: [email protected].

PMID: 34520852 DOI: 10.1016/j.jnutbio.2021.108857

Abstract

Nutritional insults early in life have been associated with metabolic diseases in adulthood. We aimed to evaluate the effects of maternal food restriction during the suckling period on metabolism and interscapular brown adipose tissue (iBAT) thermogenically involved proteins in adult rat offspring. Wistar rats underwent food restriction by 50% during the first two-thirds of lactation (FR50 group). Control rats were fed ad libitum throughout lactation (CONT group). At birth, the litter size was adjusted to eight pups, and weaning was performed at 22 days old. Body weight and food and water intake were assessed every two days. High- (HCD, 4,589 cal) and normal-caloric diet (NCD, 3,860 cal) preferences, as well as food intake during the dark part of the cycle, were assessed. At 100 days old, the rats were euthanized, and blood and tissues were removed for further analyses. Adult FR50 rats, although hyperphagic and preferring to eat HCD (P<.001), were leaner (P<.001) than the CONT group. The FR50 rats, were normoglycemic (P=.962) and had hypertriglyceridemia (P<.01). In addition, the FR50 rats were dyslipidemic (P<.01), presenting with a high atherogenic risk by the Castelli indexes (P<.01), had a higher iBAT mass (P<.01), fewer β

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Keywords: Breastfeeding; Metabolic programming; Metabolic syndrome; Perinatal undernutrition; Uncoupled protein 1

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