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Integr Med Res. 2021;10:100779. doi: 10.1016/j.imr.2021.100779. Epub 2021 Oct 01.

Honeybee products for the treatment and recovery from viral respiratory infections including SARS-COV-2: A rapid systematic review.

Integrative medicine research

Susan Arentz, Jennifer Hunter, Baljit Khamba, Michelle Mravunac, Zemirah Lee, Kristen Alexander, Romy Lauche, Joshua Goldenberg, Stephen P Myers

Affiliations

  1. NICM Health Research Institute, Western Sydney University, Sydney, NSW, Australia.
  2. Bastyr University, San Diego, CA, USA.
  3. Torrens University, Sydney, NSW, Australia.
  4. National Centre for Naturopathic Medicine, Faculty of Health, Southern Cross University, Lismore, NSW Australia.
  5. Helfgott Research Institute, National University of Natural Medicine, Portland, OR & Seattle, WA, USA.

PMID: 34611512 PMCID: PMC8483994 DOI: 10.1016/j.imr.2021.100779

Abstract

BACKGROUND: This rapid review systematically evaluated the effects of honeybee products compared to controls for the prevention, duration, severity, and recovery of acute viral respiratory tract infections (RTIs), including SARS-CoV-2, in adults and children.

METHODS: Cochrane rapid review methods were applied. Four English databases plus preprint servers and trial registries were searched for randomized controlled trials (RCTs). The evidence was appraised and synthesized using RoB 2.0 and GRADE.

RESULTS: 27 results were derived from 9 RCTs that included 674 adults and 781 children. In hospitalized adults with SARS-CoV-2, propolis plus usual-care compared to usual-care alone reduced the risk of shock, respiratory failure and kidney injury and duration of hospital admission. Honey was less effective than Guaifenesin for reducing cough severity at 60-minutes in adults with non-specific acute viral RTIs. Compared to coffee, honey plus coffee, and honey alone reduced the severity of post-infectious cough in adults. Honey reduced the duration of cough in children compared to placebo and salbutamol; and the global impact of nocturnal cough after one night compared to usual-care alone and pharmaceutical cough medicines.

CONCLUSION: More studies are needed to robustly assess honeybee's role in SARS-CoV-2 and non-specific viral respiratory infections.

PROTOCOL REGISTRATION: PROSPERO: CRD42020193847.

© 2021 Korea Institute of Oriental Medicine. Published by Elsevier B.V.

Keywords: COVID-19; Complementary medicine; Coronavirus pandemic; Long-COVID; TCIM

Conflict of interest statement

The authors declare that they have no conflicts of interest. SA and JH are editorial board members of this journal but had no role in the editorial process or decision of this paper.

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