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Borg AM, Baker JE. Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit. Synth Biol (Oxf). 2021;6(1):ysab023doi: 10.1093/synbio/ysab023.
Borg, A. M., & Baker, J. E. (2021). Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit. Synthetic biology (Oxford, England), 6(1), ysab023. https://doi.org/10.1093/synbio/ysab023
Borg, Alexander M, and Baker, John E. "Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit." Synthetic biology (Oxford, England) vol. 6,1 (2021): ysab023. doi: https://doi.org/10.1093/synbio/ysab023
Borg AM, Baker JE. Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit. Synth Biol (Oxf). 2021 Sep 02;6(1):ysab023. doi: 10.1093/synbio/ysab023. eCollection 2021. PMID: 34522784; PMCID: PMC8434797.
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Synth Biol (Oxf). 2021 Sep 02;6(1):ysab023. doi: 10.1093/synbio/ysab023. eCollection 2021.

Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit.

Synthetic biology (Oxford, England)

Alexander M Borg, John E Baker

Affiliations

  1. Departments of Biomedical Engineering and Radiation Oncology, Wake Forest University, Winston-Salem, NC, USA.
  2. Radiation Biosciences Laboratory, Medical College of Wisconsin, Milwaukee, WI, USA.

PMID: 34522784 PMCID: PMC8434797 DOI: 10.1093/synbio/ysab023

Abstract

A primary objective of the National Aeronautics and Space Administration (NASA) is expansion of humankind's presence outside low-Earth orbit, culminating in permanent interplanetary travel and habitation. Having no inherent means of physiological detection or protection against ionizing radiation, humans incur capricious risk when journeying beyond low-Earth orbit for long periods. NASA has made large investments to analyze pathologies from space radiation exposure, emphasizing the importance of characterizing radiation's physiological effects. Because natural evolution would require many generations to confer resistance against space radiation, immediately pragmatic approaches should be considered. Volitional evolution, defined as humans steering their own heredity, may inevitably retrofit the genome to mitigate resultant pathologies from space radiation exposure. Recently, uniquely radioprotective genes have been identified, conferring local or systemic radiotolerance when overexpressed

© The Author(s) 2021. Published by Oxford University Press.

Keywords: biomedical engineering modeling; human engineering ethics; interplanetary travel; ionizing space radiation; volitional evolution

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