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Guck D, Hernandez R, Moore S, et al. Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion. Case Rep Nephrol. 2021;2021:4723092doi: 10.1155/2021/4723092.
Guck, D., Hernandez, R., Moore, S., Van de Louw, A., & Haouzi, P. (2021). Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion. Case reports in nephrology, 20214723092. https://doi.org/10.1155/2021/4723092
Guck, Daniel, et al. "Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion." Case reports in nephrology vol. 2021 (2021): 4723092. doi: https://doi.org/10.1155/2021/4723092
Guck D, Hernandez R, Moore S, Van de Louw A, Haouzi P. Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion. Case Rep Nephrol. 2021 Sep 11;2021:4723092. doi: 10.1155/2021/4723092. eCollection 2021. PMID: 34552801; PMCID: PMC8452446.
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Case Rep Nephrol. 2021 Sep 11;2021:4723092. doi: 10.1155/2021/4723092. eCollection 2021.

Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion.

Case reports in nephrology

Daniel Guck, Reynaldo Hernandez, Steven Moore, Andry Van de Louw, Philippe Haouzi

Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USA.
  2. Department of Emergency Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USA.

PMID: 34552801 PMCID: PMC8452446 DOI: 10.1155/2021/4723092

Abstract

INTRODUCTION: Diquat is an herbicide that can lead to rapid multiorgan system failure upon toxic ingestion. Although Diquat shares a similar chemical structure with paraquat, diquat is still readily available to the general population, and in contrast to paraquat, it is not regulated. We present a case of an intentional diquat poisoning which emphasizes the necessity of the early recognition due to atypical symptoms within the first 24 hours and certainly enhanced regulatory restrictions on this very toxic compound.

CASE: A 60-year-old male with a history of severe depression presented to the emergency department after intentional ingestion of a commercial herbicide containing diquat dibromide 2.30%. The earliest manifestations of this acute diquat intoxication comprised a glomerulonephritis and proximal tubular dysfunction. Progressive multiorgan system failure then developed with a significant delay (24-38 hours) including acute renal, liver failure, and then respiratory failure with refractory hypoxemia. Despite maximal supportive care, the end organ failure was lethal.

Copyright © 2021 Daniel Guck et al.

Conflict of interest statement

The authors declare that there are no conflicts of interest.

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