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Clin Microbiol Rev. 2021 Oct 06;e0006421. doi: 10.1128/CMR.00064-21. Epub 2021 Oct 06.

Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases.

Clinical microbiology reviews

Timothy D Shaw, Anna D Krasnodembskaya, Gunnar N Schroeder, Alimuddin Zumla, Markus Maeurer, Cecilia M O'Kane, محمد

Affiliations

  1. Wellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast, United Kingdom.
  2. Center for Clinical Microbiology, Division of Infection and Immunity, University College Londongrid.83440.3b, NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom.
  3. Immunosurgery Unit, Champalimaud Centre for the Unknown, Lisbon, Portugal.
  4. Department of Oncology and Haematology, Krankenhaus Nordwest, Frankfurt, Germany.

PMID: 34612662 PMCID: PMC8510528 DOI: 10.1128/CMR.00064-21

Abstract

There is an urgent need for new antimicrobial strategies for treating complex infections and emerging pathogens. Human mesenchymal stromal cells (MSCs) are adult multipotent cells with antimicrobial properties, mediated through direct bactericidal activity and modulation of host innate and adaptive immune cells. More than 30

Keywords: antimicrobial; cell therapy; clinical trials; host-directed therapy; immunomodulation; immunotherapy; infectious diseases; mesenchymal stromal cells; pathogens

References

  1. Microb Pathog. 2020 Feb;139:103867 - PubMed
  2. Infect Immun. 2009 Apr;77(4):1623-35 - PubMed
  3. J Biol Chem. 2010 Aug 20;285(34):26211-22 - PubMed
  4. PLoS One. 2016 Sep 13;11(9):e0162927 - PubMed
  5. Arch Immunol Ther Exp (Warsz). 2015 Dec;63(6):427-33 - PubMed
  6. Stem Cell Res Ther. 2017 Dec 22;8(1):288 - PubMed
  7. AIDS. 2013 May 15;27(8):1283-93 - PubMed
  8. PLoS Negl Trop Dis. 2012;6(12):e1971 - PubMed
  9. Sci Rep. 2016 Jun 02;6:27326 - PubMed
  10. J Mol Med (Berl). 2019 Apr;97(4):437-450 - PubMed
  11. J Exp Med. 2009 Feb 16;206(2):299-311 - PubMed
  12. PLoS One. 2013 Aug 05;8(8):e71412 - PubMed
  13. Nat Commun. 2015 Oct 07;6:8472 - PubMed
  14. Clin Exp Immunol. 2009 Apr;156(1):149-60 - PubMed
  15. Stem Cells Transl Med. 2018 Jan;7(1):78-86 - PubMed
  16. Gut. 2009 Jul;58(7):929-39 - PubMed
  17. Lancet. 2018 Jan 6;391(10115):82-94 - PubMed
  18. Nat Rev Immunol. 2019 Jul;19(7):457-471 - PubMed
  19. Sci Rep. 2015 Mar 04;5:8733 - PubMed
  20. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3621-6 - PubMed
  21. Yeast. 2016 Apr;33(4):113-28 - PubMed
  22. FEMS Microbiol Lett. 2014 Oct;359(2):161-5 - PubMed
  23. Crit Care Med. 2018 Feb;46(2):e132-e140 - PubMed
  24. Transfusion. 2014 May;54(5):1418-37 - PubMed
  25. Stem Cells Transl Med. 2020 Jan;9(1):17-27 - PubMed
  26. Sci Rep. 2018 May 8;8(1):7296 - PubMed
  27. Blood. 2002 Jan 1;99(1):394 - PubMed
  28. Stem Cell Res Ther. 2017 Jul 4;8(1):157 - PubMed
  29. Tuberculosis (Edinb). 2016 Dec;101:130-136 - PubMed
  30. Signal Transduct Target Ther. 2021 Feb 10;6(1):58 - PubMed
  31. Methods. 2016 Apr 15;99:62-8 - PubMed
  32. J Parasit Dis. 2018 Jun;42(2):277-286 - PubMed
  33. Med Mycol. 2018 Oct 1;56(7):884-895 - PubMed
  34. Dig Dis Sci. 2017 Jan;62(1):115-123 - PubMed
  35. Stem Cell Res Ther. 2015 Apr 12;6:54 - PubMed
  36. Stem Cells Dev. 2018 Nov 1;27(21):1518-1525 - PubMed
  37. EClinicalMedicine. 2020 Jan 17;19:100249 - PubMed
  38. Cell Death Dis. 2015 Sep 17;6:e1885 - PubMed
  39. Cell Tissue Bank. 2017 Dec;18(4):443-460 - PubMed
  40. JAMA. 2016 Feb 23;315(8):801-10 - PubMed
  41. Nucl Med Biol. 2011 Oct;38(7):961-7 - PubMed
  42. Nat Commun. 2015 Mar 26;6:6692 - PubMed
  43. J Biol Chem. 2001 Mar 16;276(11):7806-10 - PubMed
  44. Eur J Immunol. 2011 Nov;41(11):3281-90 - PubMed
  45. Stem Cells Transl Med. 2021 Sep;10(9):1279-1287 - PubMed
  46. Front Physiol. 2017 Feb 14;8:89 - PubMed
  47. Clin Exp Immunol. 2017 Apr;188(1):1-11 - PubMed
  48. Stem Cell Res Ther. 2011 May 13;2(3):27 - PubMed
  49. Immunopharmacol Immunotoxicol. 2016 Jun;38(3):214-20 - PubMed
  50. Front Immunol. 2017 Aug 10;8:893 - PubMed
  51. Clin Microbiol Infect. 2019 Jul;25(7):799-806 - PubMed
  52. Obstet Gynecol. 1992 Aug;80(2):283-5 - PubMed
  53. Neurol Sci. 2011 Aug;32(4):641-51 - PubMed
  54. Pharmacol Ther. 2018 May;185:135-146 - PubMed
  55. Lancet Infect Dis. 2016 Apr;16(4):e47-63 - PubMed
  56. Theranostics. 2019 Jun 24;9(16):4633-4647 - PubMed
  57. Stem Cell Res Ther. 2019 May 17;10(1):132 - PubMed
  58. J Clin Med. 2019 Jun 13;8(6): - PubMed
  59. Nat Genet. 2001 Jul;28(3):272-5 - PubMed
  60. Cell Tissue Bank. 2016 Jun;17(2):289-302 - PubMed
  61. Antimicrob Agents Chemother. 2005 Jan;49(1):269-75 - PubMed
  62. Stem Cell Res Ther. 2015 Oct 16;6:199 - PubMed
  63. Chest. 2013 Jun;143(6):1590-1598 - PubMed
  64. Bone Marrow Transplant. 2006 Jun;37(11):1051-9 - PubMed
  65. Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1003-13 - PubMed
  66. Stem Cells Dev. 2013 Jun 15;22(12):1789-801 - PubMed
  67. Sci Rep. 2018 Oct 2;8(1):14702 - PubMed
  68. Clin Infect Dis. 2014 Jun;58(11):1571-6 - PubMed
  69. Am J Trop Med Hyg. 2011 Sep;85(3):535-9 - PubMed
  70. Science. 2020 May 29;368(6494):942-943 - PubMed
  71. Cytotherapy. 2019 Oct;21(10):1019-1024 - PubMed
  72. Stem Cells. 2015 Jun;33(6):1818-28 - PubMed
  73. Cytotherapy. 2014 Feb;16(2):181-90 - PubMed
  74. Am J Pathol. 2015 Jul;185(7):1924-34 - PubMed
  75. Immunity. 2016 Aug 16;45(2):358-73 - PubMed
  76. Sci Rep. 2016 Feb 15;6:21005 - PubMed
  77. Stem Cells Int. 2016;2016:5303048 - PubMed
  78. Nature. 2010 Aug 12;466(7308):829-34 - PubMed
  79. Am J Respir Crit Care Med. 2010 Oct 15;182(8):1047-57 - PubMed
  80. Sci Transl Med. 2019 Feb 20;11(480): - PubMed
  81. PLoS One. 2011;6(12):e28321 - PubMed
  82. Protein Pept Lett. 2011 Jan;18(1):36-40 - PubMed
  83. Semin Respir Crit Care Med. 2015 Feb;36(1):99-110 - PubMed
  84. Stem Cells Int. 2018 Apr 11;2018:4083921 - PubMed
  85. J Viral Hepat. 2008 Aug;15(8):607-14 - PubMed
  86. J Cell Mol Med. 2009 Jun;13(6):1125-35 - PubMed
  87. EMBO J. 2014 May 2;33(9):994-1010 - PubMed
  88. Sci Rep. 2016 Mar 16;6:23089 - PubMed
  89. Thorax. 2014 Sep;69(9):819-25 - PubMed
  90. Lancet Infect Dis. 2014 Nov;14(11):1136-1149 - PubMed
  91. Infect Immun. 2017 Sep 20;85(10): - PubMed
  92. Invest Ophthalmol Vis Sci. 2011 May 16;52(6):3143-52 - PubMed
  93. Thorax. 2019 Jan;74(1):43-50 - PubMed
  94. Microbes Infect. 2007 May;9(6):744-7 - PubMed
  95. iScience. 2019 May 31;15:66-78 - PubMed
  96. QJM. 2016 May;109(5):331-6 - PubMed
  97. Stem Cells. 2017 Jan;35(1):181-196 - PubMed
  98. Mol Med Rep. 2016 Oct;14(4):3862-70 - PubMed
  99. Stem Cell Res Ther. 2019 Nov 28;10(1):359 - PubMed
  100. Cytotherapy. 2013 Jun;15(6):641-8 - PubMed
  101. Stem Cells Int. 2020 Mar 28;2020:3169469 - PubMed
  102. EBioMedicine. 2015 Dec 24;4:62-73 - PubMed
  103. Int J Med Microbiol. 2018 Jan;308(1):142-147 - PubMed
  104. Lancet Respir Med. 2014 Feb;2(2):108-22 - PubMed
  105. Stem Cell Res Ther. 2020 Jan 9;11(1):21 - PubMed
  106. Respir Res. 2014 Apr 04;15:39 - PubMed
  107. J Crohns Colitis. 2020 Jan 1;14(1):64-70 - PubMed
  108. Stem Cells Transl Med. 2017 Apr;6(4):1141-1151 - PubMed
  109. World J Stem Cells. 2016 Mar 26;8(3):73-87 - PubMed
  110. Gene Ther. 2017 Jan;24(1):3-11 - PubMed
  111. Stem Cells. 2015 Jul;33(7):2331-42 - PubMed
  112. Emerg Microbes Infect. 2013 Aug;2(8):e50 - PubMed
  113. Blood. 2008 Feb 1;111(3):1327-33 - PubMed
  114. Stem Cells. 2010 Dec;28(12):2229-38 - PubMed
  115. Int J Nanomedicine. 2019 Apr 01;14:2281-2299 - PubMed
  116. Front Immunol. 2013 Mar 04;4:49 - PubMed
  117. Exp Cell Res. 2013 Aug 15;319(14):2266-74 - PubMed
  118. J Infect Dis. 2008 Feb 15;197(4):544-7 - PubMed
  119. Crit Care Med. 2016 Dec;44(12):e1236-e1245 - PubMed
  120. J Biomed Mater Res A. 2017 Sep;105(9):2640-2648 - PubMed
  121. Transplant Proc. 2006 Apr;38(3):967-9 - PubMed
  122. Anesthesiology. 2018 Sep;129(3):502-516 - PubMed
  123. Sci Rep. 2016 Dec 02;6:38308 - PubMed
  124. Lancet. 2014 Jun 28;383(9936):2253-64 - PubMed
  125. J Transl Med. 2015 Mar 15;13:92 - PubMed
  126. Cell Mol Immunol. 2017 Jan 02;: - PubMed
  127. Expert Opin Emerg Drugs. 2019 Mar;24(1):29-41 - PubMed
  128. Curr Opin Infect Dis. 2017 Dec;30(6):528-538 - PubMed
  129. Circulation. 2006 Jul 4;114(1 Suppl):I120-4 - PubMed
  130. J Orthop Res. 2010 Dec;28(12):1634-42 - PubMed
  131. Stem Cells Transl Med. 2020 Feb;9(2):235-249 - PubMed
  132. Sci Rep. 2017 Aug 29;7(1):9575 - PubMed
  133. Methods Mol Biol. 2008;449:93-107 - PubMed
  134. Intensive Care Med Exp. 2018 Aug 8;6(1):24 - PubMed
  135. Int J Mol Sci. 2019 Nov 13;20(22): - PubMed
  136. Stem Cells. 2006 Jan;24(1):74-85 - PubMed
  137. J Cell Physiol. 2010 May;223(2):530-40 - PubMed
  138. Prog Neurobiol. 2011 Oct;95(2):213-28 - PubMed
  139. Antiviral Res. 2015 May;117:75-98 - PubMed
  140. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16357-62 - PubMed
  141. Aging Dis. 2020 Mar 9;11(2):216-228 - PubMed
  142. Mol Med Rep. 2017 May;15(5):2551-2559 - PubMed
  143. J Cell Physiol. 2015 Mar;230(3):691-701 - PubMed
  144. J Stem Cell Res Ther. 2017 Aug;7(9): - PubMed
  145. Cell Microbiol. 2016 Mar;18(3):424-36 - PubMed
  146. Stem Cells. 2014 Jan;32(1):116-25 - PubMed
  147. J Aerosol Med Pulm Drug Deliv. 2020 Jun;33(3):140-152 - PubMed
  148. Stem Cells Transl Med. 2013 Nov;2(11):884-95 - PubMed
  149. Stem Cells Transl Med. 2020 Jan;9(1):28-38 - PubMed
  150. Cytotherapy. 2006;8(4):315-7 - PubMed
  151. Exp Cell Res. 2021 Feb 15;399(2):112473 - PubMed
  152. PLoS Negl Trop Dis. 2012;6(10):e1864 - PubMed
  153. Stem Cell Rev Rep. 2013 Feb;9(1):65-79 - PubMed
  154. Cell Transplant. 2011;20(11-12):1843-54 - PubMed
  155. Oncotarget. 2017 Sep 8;8(56):95495-95503 - PubMed
  156. PLoS One. 2020 Jan 27;15(1):e0227460 - PubMed
  157. Eur J Haematol. 2018 Jun;100(6):624-629 - PubMed
  158. BMC Pulm Med. 2016 Jan 23;16:19 - PubMed
  159. Int J Mol Sci. 2014 Apr 10;15(4):6096-110 - PubMed
  160. Stem Cells. 2011 Oct;29(10):1549-58 - PubMed
  161. Skeletal Radiol. 2008 Dec;37(12):1129-33 - PubMed
  162. Eur Respir J. 2018 Apr 26;51(4): - PubMed
  163. Stem Cells Transl Med. 2013 Jun;2(6):455-63 - PubMed
  164. Blood. 2006 Jan 1;107(1):367-72 - PubMed
  165. J Immunol. 2015 Aug 1;195(3):875-81 - PubMed
  166. J Immunol. 2007 Aug 1;179(3):1855-63 - PubMed
  167. Science. 1999 Apr 2;284(5411):143-7 - PubMed
  168. J Biol Chem. 2011 Apr 29;286(17):14932-40 - PubMed
  169. Arch Gynecol Obstet. 2019 Aug;300(2):421-429 - PubMed
  170. Am J Physiol Lung Cell Mol Physiol. 2020 Dec 1;319(6):L908-L925 - PubMed
  171. Am J Respir Cell Mol Biol. 2013 Oct;49(4):552-62 - PubMed
  172. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 1;307(5):L395-406 - PubMed
  173. Immunol Lett. 2015 Dec;168(2):140-6 - PubMed
  174. Med Microbiol Immunol. 2013 Jun;202(3):197-206 - PubMed
  175. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1409-15 - PubMed
  176. Exp Biol Med (Maywood). 2012 May;237(5):585-92 - PubMed
  177. Front Immunol. 2017 Mar 30;8:339 - PubMed
  178. Stem Cells Transl Med. 2017 Mar;6(3):962-969 - PubMed
  179. J Inflamm (Lond). 2014 Jan 07;11(1):1 - PubMed
  180. Expert Rev Anti Infect Ther. 2011 Apr;9(4):415-30 - PubMed
  181. Cytotherapy. 2017 Oct;19(10):1152-1166 - PubMed
  182. PLoS One. 2014 May 05;9(5):e96681 - PubMed
  183. PLoS One. 2013 Aug 15;8(8):e71761 - PubMed
  184. J Invest Dermatol. 2015 Feb;135(2):612-615 - PubMed
  185. Int J Stem Cells. 2016 May 30;9(1):96-106 - PubMed
  186. J Infect Dis. 2019 Jan 7;219(2):186-196 - PubMed
  187. Nature. 2020 Jul;583(7818):830-833 - PubMed
  188. Stem Cells. 2006 Dec;24(12):2744-52 - PubMed
  189. Front Microbiol. 2020 Jan 10;10:2980 - PubMed
  190. Equine Vet J. 2020 Sep;52(5):654-663 - PubMed
  191. Pathogens. 2015 Aug 12;4(3):606-19 - PubMed
  192. Am J Respir Crit Care Med. 2013 Apr 1;187(7):751-60 - PubMed
  193. Science. 2020 May 29;368(6494):1016-1020 - PubMed
  194. Am J Pathol. 2004 Feb;164(2):441-7 - PubMed
  195. Antimicrob Agents Chemother. 2001 Oct;45(10):2838-44 - PubMed
  196. Front Cell Dev Biol. 2021 Jan 08;8:598520 - PubMed
  197. Biosci Rep. 2019 Sep 16;39(9): - PubMed
  198. Cell Biol Int. 2017 Sep;41(9):969-981 - PubMed
  199. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41 - PubMed
  200. Stem Cells. 2009 Jan;27(1):126-37 - PubMed
  201. Nat Rev Immunol. 2016 May;16(5):321-34 - PubMed
  202. J Exp Med. 2011 Mar 14;208(3):421-8 - PubMed
  203. Biotechnol Prog. 2017 Sep;33(5):1358-1367 - PubMed
  204. Blood. 2005 Dec 15;106(13):4057-65 - PubMed
  205. Cell Biol Int. 2016 Jan;40(1):27-35 - PubMed
  206. Lancet. 2016 Sep 24;388(10051):1281-90 - PubMed
  207. J Stem Cell Res Ther. 2016 Nov;6(11): - PubMed
  208. Front Immunol. 2013 Jul 03;4:143 - PubMed
  209. Expert Rev Respir Med. 2021 Mar;15(3):301-324 - PubMed
  210. Stem Cells. 2016 Aug;34(8):2210-23 - PubMed
  211. F1000Res. 2016 Jun 28;5: - PubMed
  212. Front Physiol. 2018 Nov 13;9:1572 - PubMed
  213. Stem Cells Transl Med. 2016 Sep;5(9):1190-203 - PubMed
  214. Respir Res. 2015 Oct 06;16:123 - PubMed
  215. Sci Rep. 2017 Nov 8;7(1):15010 - PubMed
  216. Stem Cell Res Ther. 2016 Jan 11;7:7 - PubMed
  217. J Leukoc Biol. 2007 Oct;82(4):934-45 - PubMed
  218. Thorax. 2018 Jun;73(6):565-574 - PubMed
  219. J Immunol Res. 2019 Apr 14;2019:1356540 - PubMed
  220. Stem Cell Res Ther. 2019 Nov 26;10(1):348 - PubMed
  221. PLoS Med. 2007 Sep;4(9):e269 - PubMed
  222. Immune Netw. 2011 Oct;11(5):245-52 - PubMed
  223. Nat Med. 2009 Jan;15(1):42-9 - PubMed
  224. Stem Cells. 2016 Jul;34(7):1957-70 - PubMed
  225. Blood. 2002 Dec 1;100(12):4193-200 - PubMed
  226. Arch Med Res. 2009 Nov;40(8):655-61 - PubMed
  227. Stem Cells. 2014 Jun;32(6):1616-28 - PubMed
  228. BMC Med. 2016 Jun 15;14:89 - PubMed
  229. Ann N Y Acad Sci. 2007 Jun;1106:262-71 - PubMed
  230. Am J Respir Crit Care Med. 2015 Aug 1;192(3):324-36 - PubMed
  231. Exp Hematol. 2003 Oct;31(10):890-6 - PubMed
  232. PLoS One. 2013 Dec 18;8(12):e83303 - PubMed
  233. PLoS One. 2014 Sep 19;9(9):e106903 - PubMed
  234. Sci Rep. 2016 Jul 26;6:30263 - PubMed
  235. Leukemia. 2011 Sep;25(9):1408-14 - PubMed
  236. Microb Pathog. 2011 Feb;50(2):132-9 - PubMed
  237. BMC Immunol. 2014 Jan 14;15:1 - PubMed
  238. Diabetes. 2009 Mar;58(3):718-25 - PubMed
  239. Stem Cells. 2015 Mar;33(3):880-91 - PubMed
  240. Stem Cell Res Ther. 2018 Feb 26;9(1):45 - PubMed
  241. PLoS One. 2014 Oct 22;9(10):e110338 - PubMed
  242. Nat Med. 2012 Apr 15;18(5):759-65 - PubMed
  243. Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347 - PubMed
  244. Stem Cells Transl Med. 2017 Dec;6(12):2173-2185 - PubMed
  245. Stem Cell Res Ther. 2017 Apr 18;8(1):89 - PubMed
  246. Thorax. 2015 Jul;70(7):625-35 - PubMed
  247. Cells. 2019 May 15;8(5): - PubMed
  248. Hepatology. 2011 Sep 2;54(3):820-8 - PubMed
  249. Thorax. 2012 Jun;67(6):533-9 - PubMed
  250. Cell Immunol. 2012 Nov;280(1):22-35 - PubMed
  251. Leukemia. 2011 Apr;25(4):648-54 - PubMed
  252. Immunobiology. 2013 Jan;218(1):90-5 - PubMed
  253. Appl Microbiol Biotechnol. 2018 May;102(9):3981-3994 - PubMed
  254. Immunity. 2014 Nov 20;41(5):802-14 - PubMed
  255. Am J Pathol. 2014 Dec;184(12):3170-5 - PubMed
  256. Med Mycol. 2021 Feb 4;59(2):149-157 - PubMed
  257. J Clin Transl Hepatol. 2014 Dec;2(4):217-21 - PubMed
  258. Transplantation. 2007 Mar 27;83(6):783-90 - PubMed
  259. Tissue Eng Part B Rev. 2010 Apr;16(2):159-68 - PubMed
  260. Cell Res. 2013 Jan;23(1):107-21 - PubMed
  261. Am J Respir Crit Care Med. 2014 Jun 15;189(12):1520-9 - PubMed
  262. PLoS One. 2015 Sep 18;10(9):e0138477 - PubMed
  263. Cell Transplant. 2012;21(1):207-16 - PubMed
  264. Stem Cells Transl Med. 2021 Aug;10(8):1202-1216 - PubMed
  265. Blood. 2005 Mar 1;105(5):2214-9 - PubMed
  266. BMC Ophthalmol. 2019 Nov 14;19(1):226 - PubMed
  267. Am J Physiol Lung Cell Mol Physiol. 2016 May 1;310(9):L868-79 - PubMed
  268. Blood Adv. 2018 May 22;2(10):1089-1100 - PubMed
  269. Cytotherapy. 2017 Jul;19(7):784-797 - PubMed
  270. Stem Cell Rev Rep. 2019 Feb;15(1):112-125 - PubMed
  271. PLoS One. 2012;7(10):e47559 - PubMed
  272. Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286 - PubMed
  273. Cytotherapy. 2019 Mar;21(3):289-306 - PubMed
  274. Stem Cells Transl Med. 2020 Jul;9(7):746-757 - PubMed
  275. Cytotherapy. 2014 Jan;16(1):56-63 - PubMed
  276. Cell Transplant. 2013;22(6):977-91 - PubMed
  277. Stem Cells Dev. 2009 Jun;18(5):683-92 - PubMed
  278. Sci Rep. 2017 Jun 27;7(1):4265 - PubMed
  279. Microbe Wash DC. 2008 Sep;3(9):416-423 - PubMed
  280. Stem Cells. 2016 Jul;34(7):1909-21 - PubMed
  281. PLoS One. 2015 May 18;10(5):e0126994 - PubMed
  282. Eur J Immunol. 2013 Aug;43(8):2070-7 - PubMed

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