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Owji AP, Kittredge A, Zhang Y, et al. Structure and Function of the Bestrophin family of calcium-activated chloride channels. Channels (Austin). 2021;15(1):604-623doi: 10.1080/19336950.2021.1981625.
Owji, A. P., Kittredge, A., Zhang, Y., & Yang, T. (2021). Structure and Function of the Bestrophin family of calcium-activated chloride channels. Channels (Austin, Tex.), 15(1), 604-623. https://doi.org/10.1080/19336950.2021.1981625
Owji, Aaron P, et al. "Structure and Function of the Bestrophin family of calcium-activated chloride channels." Channels (Austin, Tex.) vol. 15,1 (2021): 604-623. doi: https://doi.org/10.1080/19336950.2021.1981625
Owji AP, Kittredge A, Zhang Y, Yang T. Structure and Function of the Bestrophin family of calcium-activated chloride channels. Channels (Austin). 2021 Dec;15(1):604-623. doi: 10.1080/19336950.2021.1981625. PMID: 34612806; PMCID: PMC8496536.
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Channels (Austin). 2021 Dec;15(1):604-623. doi: 10.1080/19336950.2021.1981625.

Structure and Function of the Bestrophin family of calcium-activated chloride channels.

Channels (Austin, Tex.)

Aaron P Owji, Alec Kittredge, Yu Zhang, Tingting Yang

Affiliations

  1. Department of Pharmacology, Columbia University, NY, USA.
  2. Department of Ophthalmology, Columbia University, NY, USA.

PMID: 34612806 PMCID: PMC8496536 DOI: 10.1080/19336950.2021.1981625

Abstract

Bestrophins are a family of calcium-activated chloride channels (CaCCs) with relevance to human physiology and a myriad of eye diseases termed "bestrophinopathies". Since the identification of bestrophins as CaCCs nearly two decades ago, extensive studies from electrophysiological and structural biology perspectives have sought to define their key channel features including calcium sensing, gating, inactivation, and anion selectivity. The initial X-ray crystallography studies on the prokaryotic homolog of Best1,

Keywords: Best1; Best2; Bestrophin function; Bestrophins; bestrophin structure

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