J Ophthalmic Inflamm Infect. 2021 Nov 01;11(1):31. doi: 10.1186/s12348-021-00263-1.
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE).
Journal of ophthalmic inflammation and infection
Ilaria Testi, Sandra Vermeirsch, Carlos Pavesio
Affiliations
Affiliations
- Department of Uveitis, Moorfields Eye Hospital, National Health Service Foundation Trust, 162 City Rd, Old Street, London, EC1V 2PD, UK.
- Department of Uveitis, Moorfields Eye Hospital, National Health Service Foundation Trust, 162 City Rd, Old Street, London, EC1V 2PD, UK. [email protected].
PMID: 34524577
PMCID: PMC8443720 DOI: 10.1186/s12348-021-00263-1
Abstract
BACKGROUND: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory eye disease, affecting the inner choroid and the outer retina. Recent advances in multimodal imaging have been important in the understanding of the pathophysiology of the disease, allowing a better characterization of the morphology of this condition.
METHODS: Narrative review.
RESULTS: In this review, a comprehensive overview of clinical features, imaging findings, treatment management, and long-term outcomes of patients with APMPPE will be provided.
CONCLUSIONS: Although APMPPE was originally believed to be a self-limited condition with a good prognosis, the disease can be recurrent and result in significant loss of vision function. Fundus imaging plays an important role in the diagnosis and management of the disease, allowing to evaluate response to treatment and onset of complications.
© 2021. The Author(s).
Keywords: APMPPE; Acute posterior multifocal placoid pigment epitheliopathy; Imaging; Optical coherence tomography angiography; Placoid epiteliopathy
References
- Arch Ophthalmol. 1968 Aug;80(2):177-85 - PubMed
- Retin Cases Brief Rep. 2021 Jul 1;15(4):391-398 - PubMed
- J Ophthalmic Inflamm Infect. 2012 Sep;2(3):125-31 - PubMed
- Ophthalmology. 1995 Dec;102(12):1877-83 - PubMed
- Eye (Lond). 2017 Oct;31(10):1399-1408 - PubMed
- Ocul Immunol Inflamm. 2011 Dec;19(6):426-30 - PubMed
- Retin Cases Brief Rep. 2019 Nov 19;: - PubMed
- J Clin Exp Ophthalmol. 2016 Jun;7(3): - PubMed
- Retina. 2009 Jul-Aug;29(7):994-1001 - PubMed
- Rom J Ophthalmol. 2015 Jan-Mar;59(1):52-8 - PubMed
- Am J Ophthalmol. 1975 Dec;80(6):1003-5 - PubMed
- Retin Cases Brief Rep. 2020 Jan 27;: - PubMed
- Case Rep Ophthalmol Med. 2020 Mar 13;2020:7049168 - PubMed
- Am J Ophthalmol Case Rep. 2016 Aug 31;4:60-63 - PubMed
- J Ophthalmic Vis Res. 2011 Oct;6(4):338-43 - PubMed
- Arch Ophthalmol. 1990 May;108(5):698-700 - PubMed
- Diagnostics (Basel). 2021 May 24;11(6): - PubMed
- Cir Cir. 2016 Mar-Apr;84(2):135-9 - PubMed
- Ocul Immunol Inflamm. 2020 Nov 16;28(8):1223-1238 - PubMed
- Case Rep Ophthalmol Med. 2019 Jul 9;2019:9217656 - PubMed
- Neurologist. 2020 Sep;25(5):131-136 - PubMed
- Br J Ophthalmol. 2010 Mar;94(3):282-3, 363 - PubMed
- J Fr Ophtalmol. 2020 Feb;43(2):e55-e66 - PubMed
- Ophthalmic Surg Lasers Imaging Retina. 2019 Jul 1;50(7):428-436 - PubMed
- J Ophthalmic Inflamm Infect. 2018 Sep 12;8(1):13 - PubMed
- Ocul Immunol Inflamm. 2011 Feb;19(1):42-7 - PubMed
- Semin Ophthalmol. 2012 Sep-Nov;27(5-6):228-35 - PubMed
- Br J Ophthalmol. 1995 Apr;79(4):384-9 - PubMed
- J Clin Neurosci. 2016 Sep;31:76-80 - PubMed
- Retina. 2012 Jul;32(7):1403-10 - PubMed
- Ophthalmic Surg Lasers Imaging Retina. 2016 Jan;47(1):20-6 - PubMed
- Ann Ophthalmol. 1992 May;24(5):169-73 - PubMed
- Br J Ophthalmol. 1988 Jan;72(1):74-7 - PubMed
- Acta Ophthalmol (Copenh). 1994 Feb;72(1):128-33 - PubMed
- Saudi J Ophthalmol. 2014 Apr;28(2):95-103 - PubMed
- Arch Ophthalmol. 1995 Mar;113(3):297-300 - PubMed
- Ophthalmol Retina. 2020 Apr;4(4):454-456 - PubMed
- PLoS One. 2020 Aug 24;15(8):e0238080 - PubMed
- Int Ophthalmol Clin. 2016 Fall;56(4):175-201 - PubMed
- Retina. 1995;15(4):351-2 - PubMed
- Ophthalmol Retina. 2017 Jan - Feb;1(1):77-91 - PubMed
- J Vitreoretin Dis. 2020 Jun 1;4(3):192-201 - PubMed
- J Clin Neurol. 2016 Oct;12(4):460-467 - PubMed
- Curr Opin Ophthalmol. 2004 Dec;15(6):519-30 - PubMed
- Eye (Lond). 2010 Jan;24(1):180-1 - PubMed
- Am J Ophthalmol. 1976 Apr;81(4):403-12 - PubMed
- Int J Retina Vitreous. 2017 Mar 20;3:12 - PubMed
- J Curr Ophthalmol. 2020 Dec 12;32(4):381-389 - PubMed
- Stroke. 1996 May;27(5):996-1001 - PubMed
- Ocul Immunol Inflamm. 2020 Sep 23;:1-4 - PubMed
- Eye (Lond). 2021 Jan;35(1):33-51 - PubMed
- Br J Ophthalmol. 1996 Feb;80(2):186 - PubMed
- Graefes Arch Clin Exp Ophthalmol. 2006 Oct;244(10):1219-23 - PubMed
- Retin Cases Brief Rep. 2019 Nov 08;: - PubMed
- Retina. 2005 Dec;25(8):1109-12 - PubMed
- Retina. 2017 Nov;37(11):2084-2094 - PubMed
Publication Types