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Çelen S, Öngöz Dede F, Avşar C. Role of Inhibitor SMADs in Stage 3 Grade B periodontitis before and after periodontal treatment. J Periodontal Res. 2021;doi: 10.1111/jre.12935.
Çelen, S., Öngöz Dede, F., & Avşar, C. (2021). Role of Inhibitor SMADs in Stage 3 Grade B periodontitis before and after periodontal treatment. Journal of periodontal research, . https://doi.org/10.1111/jre.12935
Çelen, Selman, et al. "Role of Inhibitor SMADs in Stage 3 Grade B periodontitis before and after periodontal treatment." Journal of periodontal research vol. (2021). doi: https://doi.org/10.1111/jre.12935
Çelen S, Öngöz Dede F, Avşar C. Role of Inhibitor SMADs in Stage 3 Grade B periodontitis before and after periodontal treatment. J Periodontal Res. 2021 Sep 28; doi: 10.1111/jre.12935. Epub 2021 Sep 28. PMID: 34581437.
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J Periodontal Res. 2021 Sep 28; doi: 10.1111/jre.12935. Epub 2021 Sep 28.

Role of Inhibitor SMADs in Stage 3 Grade B periodontitis before and after periodontal treatment.

Journal of periodontal research

Selman Çelen, Figen Öngöz Dede, Candeğer Avşar

Affiliations

  1. Department of Periodontology, Faculty of Dentistry, Ordu University, Ordu, Turkey.
  2. Faculty of Medicine, Department of Medical Biochemistry, ?zmir Katip Çelebi University, ?zmir, Turkey.

PMID: 34581437 DOI: 10.1111/jre.12935

Abstract

OBJECTIVE: This study aimed to examine the levels of transforming growth factor-beta (TGF-β) and inhibitory-Smads (I-Smads) in saliva and gingival crevicular fluid (GCF) in patients with Stage 3 Grade B periodontitis before and after non-surgical periodontal treatment.

BACKGROUND: Recently, it has been stated that Smads play an active role in all conditions where TGF-β is involved, including periodontal inflammation.

METHODS: Twenty healthy participants (control) and 20 patients with Stage 3, Grade B periodontitis were recruited. GCF and saliva samples and clinical periodontal recordings were investigated at the baseline and 1 month after treatment. TGF-β and I-Smads (Smads 6 and 7) were determined by ELISA.

RESULTS: Salivary Smad6 and Smad7 levels were significantly lower in the periodontitis group than healthy controls (p < .05), while there was no difference in salivary TGF-β levels between groups at baseline (p > .05). The total amounts and concentrations of GCF TGF-β, Smad6, and Smad7 were significantly lower in the periodontitis group than healthy controls at baseline (p < .05), and then decreased in concentration levels with treatment (p < .001). Positive correlations were found between total amounts and concentrations of GCF TGF-β, Smad6, and Smad7 (p < .05).

CONCLUSION: Our findings revealed that Smad6 and Smad7 in GCF and saliva decreased in periodontitis and then increased after periodontal treatment. Our study suggests that I-Smads act in parallel with TGF-β in periodontal inflammation and may have a role in the development of periodontitis.

© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Keywords: Smad6; Smad7; TGF-β; gingival crevicular fluid; non-surgical periodontal treatment; periodontitis; saliva

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