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Mansoor S, Maheshwari A, Di Guglielmo M, et al. The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity. Pediatr Gastroenterol Hepatol Nutr. 2021;24(5):455-469doi: 10.5223/pghn.2021.24.5.455.
Mansoor, S., Maheshwari, A., Di Guglielmo, M., Furuya, K., Wang, M., Crowgey, E., Molle-Rios, Z., & He, Z. (2021). The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity. Pediatric gastroenterology, hepatology & nutrition, 24(5), 455-469. https://doi.org/10.5223/pghn.2021.24.5.455
Mansoor, Sana, et al. "The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity." Pediatric gastroenterology, hepatology & nutrition vol. 24,5 (2021): 455-469. doi: https://doi.org/10.5223/pghn.2021.24.5.455
Mansoor S, Maheshwari A, Di Guglielmo M, Furuya K, Wang M, Crowgey E, Molle-Rios Z, He Z. The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity. Pediatr Gastroenterol Hepatol Nutr. 2021 Sep;24(5):455-469. doi: 10.5223/pghn.2021.24.5.455. Epub 2021 Sep 08. PMID: 34557398; PMCID: PMC8443857.
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Pediatr Gastroenterol Hepatol Nutr. 2021 Sep;24(5):455-469. doi: 10.5223/pghn.2021.24.5.455. Epub 2021 Sep 08.

The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity.

Pediatric gastroenterology, hepatology & nutrition

Sana Mansoor, Anshu Maheshwari, Matthew Di Guglielmo, Katryn Furuya, Makala Wang, Erin Crowgey, Zarela Molle-Rios, Zhaoping He

Affiliations

  1. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.
  2. Department of Pediatrics, Sidney Kimmel Medical College Thomas Jefferson University, Philadelphia, PA, USA.
  3. Department of Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.

PMID: 34557398 PMCID: PMC8443857 DOI: 10.5223/pghn.2021.24.5.455

Abstract

PURPOSE: The rs641738 C>T in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is implicated, along with the rs738409 C>G polymorphism in patatin-like phospholipase domain-containing protein 3 (PNPLA3), in nonalcoholic fatty liver disease (NAFLD). The association of these polymorphisms and NAFLD are investigated in Hispanic children with obesity.

METHODS: Obese children with and without NAFLD were enrolled at a pediatric tertiary care health system and genotyped for MBOAT7 rs641738 C>T and PNPLA3 rs738409 C>G. NAFLD was characterized by the ultrasonographic presence of hepatic steatosis along with persistently elevated liver enzymes. Genetic variants and demographic and biochemical data were analyzed for the effects on NAFLD.

RESULTS: Among 126 enrolled subjects, 84 in the case group had NAFLD and 42 in the control group did not. The two groups had similar demographic distribution. NAFLD was associated with abnormal liver enzymes and elevated triglycerides and cholesterol (

CONCLUSION: In Hispanic children with obesity, PNPLA3 rs738409 C>G polymorphism increased the risk for NAFLD. The role of MBOAT7 rs641738 variant in NAFLD is less evident.

Copyright © 2021 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.

Keywords: Hispanic Americans; Lipid metabolism; Nonalcoholic fatty liver disease; Pediatric obesity; Polymorphism, genetic

Conflict of interest statement

Conflict of Interest: The authors have no financial conflicts of interest.

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