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Yilmaz H, Cakir M, Komurcu SZM, et al. Evaluation of patients with COVID-19 and the United Kingdom mutations in a training and research hospital in Istanbul. North Clin Istanb. 2021;8(4):317-320doi: 10.14744/nci.2021.90947.
Yilmaz, H., Cakir, M., Komurcu, S. Z. M., Kazezoglu, C., Guner, A. E., Memisoglu, K., & Maral, I. (2021). Evaluation of patients with COVID-19 and the United Kingdom mutations in a training and research hospital in Istanbul. Northern clinics of Istanbul, 8(4), 317-320. https://doi.org/10.14744/nci.2021.90947
Yilmaz, Habip, et al. "Evaluation of patients with COVID-19 and the United Kingdom mutations in a training and research hospital in Istanbul." Northern clinics of Istanbul vol. 8,4 (2021): 317-320. doi: https://doi.org/10.14744/nci.2021.90947
Yilmaz H, Cakir M, Komurcu SZM, Kazezoglu C, Guner AE, Memisoglu K, Maral I. Evaluation of patients with COVID-19 and the United Kingdom mutations in a training and research hospital in Istanbul. North Clin Istanb. 2021 Aug 19;8(4):317-320. doi: 10.14744/nci.2021.90947. eCollection 2021. PMID: 34585064; PMCID: PMC8430359.
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North Clin Istanb. 2021 Aug 19;8(4):317-320. doi: 10.14744/nci.2021.90947. eCollection 2021.

Evaluation of patients with COVID-19 and the United Kingdom mutations in a training and research hospital in Istanbul.

Northern clinics of Istanbul

Habip Yilmaz, Mustafa Cakir, Selen Zeliha Mart Komurcu, Cemal Kazezoglu, Abdullah Emre Guner, Kemal Memisoglu, Isil Maral

Affiliations

  1. Istanbul Health Directorate, Istanbul, Turkey.
  2. Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey.
  3. Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
  4. Health Sciences University Hamidiye Faculty of Medicine, Istanbul, Turkey.

PMID: 34585064 PMCID: PMC8430359 DOI: 10.14744/nci.2021.90947

Abstract

OBJECTIVE: This study aims to evaluate the patient clinics by studying Variant of Concern (VOC) Polymerase Chain Reaction (PCR) on conventional PCR-positive samples in a training and research hospital COVID test center in Istanbul.

METHODS: The study is a descriptive type and VOC PCR from all samples (from a total of 1300 samples) which detected positive by conventional PCR in a training and research hospital COVID test center between February 2 and 9, 2021. The United Kingdom mutation (VOC 202012/01, B.1.1.7) has been studied. Clinics parameters of the patients were evaluated from Public Health Management System (HSYS) records. The statistical significance was taken as p<0.05 in the analysis.

RESULTS: Within the scope of the research, 1300 PCR-positive COVID-19 patients were evaluated. VOC mutation was positive in 26.1% of all patients (339 persons), and 5.8% of patients (75 persons) were hospitalized. While 3.2% (11 persons) of those with VOC positivity were hospitalized, 6.7% (64 persons) of VOC negatives were hospitalized (p=0.020). About 18.2% of hospitalized VOC positives (two persons) and 23.4% of VOC negatives (15 persons) are in intensive care.

CONCLUSION: When VOC mutation was examined in all admitted and hospitalized patients, it was detected that VOC mutation was less frequent in hospitalized patients. No relationship between hospitalization and intensive care stay and VOC mutation was detected. It is recommended to determine with studies the contagiousness of patients with VOC mutations.

Copyright: © 2021 by Istanbul Northern Anatolian Association of Public Hospitals.

Keywords: COVID-19; mutation; patients

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

References

  1. Science. 2020 Sep 4;369(6508):1255-1260 - PubMed
  2. Euro Surveill. 2021 Jan;26(1): - PubMed
  3. Science. 2021 Jan 8;371(6525):108-109 - PubMed

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