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Martí-Carvajal AJ, Knight-Madden JM, Martinez-Zapata MJ. Interventions for treating leg ulcers in people with sickle cell disease. Cochrane Database Syst Rev. 2021;1:CD008394doi: 10.1002/14651858.CD008394.pub4.
Martí-Carvajal, A. J., Knight-Madden, J. M., & Martinez-Zapata, M. J. (2021). Interventions for treating leg ulcers in people with sickle cell disease. The Cochrane database of systematic reviews, 1CD008394. https://doi.org/10.1002/14651858.CD008394.pub4
Martí-Carvajal, Arturo J, et al. "Interventions for treating leg ulcers in people with sickle cell disease." The Cochrane database of systematic reviews vol. 1 (2021): CD008394. doi: https://doi.org/10.1002/14651858.CD008394.pub4
Martí-Carvajal AJ, Knight-Madden JM, Martinez-Zapata MJ. Interventions for treating leg ulcers in people with sickle cell disease. Cochrane Database Syst Rev. 2021 Jan 09;1:CD008394. doi: 10.1002/14651858.CD008394.pub4. PMID: 34559425; PMCID: PMC8407242.
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Cochrane Database Syst Rev. 2021 Jan 09;1:CD008394. doi: 10.1002/14651858.CD008394.pub4.

Interventions for treating leg ulcers in people with sickle cell disease.

The Cochrane database of systematic reviews

Arturo J Martí-Carvajal, Jennifer M Knight-Madden, Maria José Martinez-Zapata

Affiliations

  1. Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE (Cochrane Ecuador), Quito, Ecuador.
  2. School of Medicine, Universidad Francisco de Vitoria (Cochrane Madrid), Madrid, Spain.
  3. Sickle Cell Unit, Tropical Medicine Research Institute, Kingston 7, Jamaica.
  4. Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau), CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

PMID: 34559425 PMCID: PMC8407242 DOI: 10.1002/14651858.CD008394.pub4

Abstract

BACKGROUND: The frequency of skin ulceration makes an important contributor to the morbidity burden in people with sickle cell disease. Many treatment options are available to the healthcare professional, although it is uncertain which treatments have been assessed for effectiveness in people with sickle cell disease. This is an update of a previously published Cochrane Review.

OBJECTIVES: To assess the clinical effectiveness and harms of interventions for treating leg ulcers in people with sickle cell disease.

SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register. We searched LILACS (1982 to January 2020), ISI Web of Knowledge (1985 to January 2020), and the Clinical Trials Search Portal of the World Health Organization (January 2020). We checked the reference lists of all the trials identified. We also contacted those groups or individuals who may have completed relevant randomised trials in this area. Date of the last search of the Cochrane Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register: 13 January 2020; date of the last search of the Cochrane Wounds Group Trials Register: 17 February 2017.

SELECTION CRITERIA: Randomised controlled trials of interventions for treating leg ulcers in people with sickle cell disease compared to placebo or an alternative treatment.

DATA COLLECTION AND ANALYSIS: Two authors independently selected studies for inclusion. All three authors independently assessed the risk of bias of the included studies and extracted data. We used GRADE to assess the quality of the evidence.

MAIN RESULTS: Six studies met the inclusion criteria (198 participants with 250 ulcers). Each trial investigated a different intervention and within this review we have grouped these as systemic pharmaceutical interventions (L-cartinine, arginine butyrate, isoxsuprine) and topical pharmaceutical interventions (Solcoseryl

AUTHORS' CONCLUSIONS: Given the very low quality of the evidence identified in this updated Cochrane Review we are uncertain whether any of the assessed pharmaceutical interventions reduce ulcer size or result in leg ulcer closure in treated participants compared to controls. However, this intervention was assessed as having a high risk of bias due to inadequacies in the single trial report. Other included studies were also assessed as having an unclear or high risk of bias. The harm profile of the all interventions remains inconclusive.

Copyright © 2021 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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