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Villarejo-Zori B, Jiménez-Loygorri JI, Zapata-Muñoz J, et al. New insights into the role of autophagy in retinal and eye diseases. Mol Aspects Med. 2021;82:101038doi: 10.1016/j.mam.2021.101038.
Villarejo-Zori, B., Jiménez-Loygorri, J. I., Zapata-Muñoz, J., Bell, K., & Boya, P. (2021). New insights into the role of autophagy in retinal and eye diseases. Molecular aspects of medicine, 82101038. https://doi.org/10.1016/j.mam.2021.101038
Villarejo-Zori, Beatriz, et al. "New insights into the role of autophagy in retinal and eye diseases." Molecular aspects of medicine vol. 82 (2021): 101038. doi: https://doi.org/10.1016/j.mam.2021.101038
Villarejo-Zori B, Jiménez-Loygorri JI, Zapata-Muñoz J, Bell K, Boya P. New insights into the role of autophagy in retinal and eye diseases. Mol Aspects Med. 2021 Dec;82:101038. doi: 10.1016/j.mam.2021.101038. Epub 2021 Oct 05. PMID: 34620506.
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Mol Aspects Med. 2021 Dec;82:101038. doi: 10.1016/j.mam.2021.101038. Epub 2021 Oct 05.

New insights into the role of autophagy in retinal and eye diseases.

Molecular aspects of medicine

Beatriz Villarejo-Zori, Juan Ignacio Jiménez-Loygorri, Juan Zapata-Muñoz, Katharina Bell, Patricia Boya

Affiliations

  1. Department of Cellular and Molecular Biology, Margarita Salas Center for Biological Research, CSIC, Ramiro de Maetzu, 9, 28040, Madrid, Spain.
  2. Singapore Eye Research Institute, Singapore National Eye Centre, Republic of Singapore.
  3. Department of Cellular and Molecular Biology, Margarita Salas Center for Biological Research, CSIC, Ramiro de Maetzu, 9, 28040, Madrid, Spain. Electronic address: [email protected].

PMID: 34620506 DOI: 10.1016/j.mam.2021.101038

Abstract

Autophagy is a fundamental homeostatic pathway that mediates the degradation and recycling of intracellular components. It serves as a key quality control mechanism, especially in non-dividing cells such as neurons. Proteins, lipids, and even whole organelles are engulfed in autophagosomes and delivered to the lysosome for elimination. The retina is a light-sensitive tissue located in the back of the eye that detects and processes visual images. Vision is a highly demanding process, making the eye one of the most metabolically active tissues in the body and photoreceptors display glycolytic metabolism, even in the presence of oxygen. The retina and eye are also exposed to other stressors that can impair their function, including genetic mutations and age-associated changes. Autophagy, among other pathways, is therefore a key process for the preservation of retinal homeostasis. Here, we review the roles of both canonical and non-canonical autophagy in normal retinal function. We discuss the most recent studies investigating the participation of autophagy in eye diseases such as age-related macular degeneration, glaucoma, and diabetic retinopathy and its role protecting photoreceptors in several forms of retinal degeneration. Finally, we consider the therapeutic potential of strategies that target autophagy pathways to treat prevalent retinal and eye diseases.

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords: Autophagy; Glaucoma; Macular degeneration; Retina; Retinal dystrophies

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