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Zhao Z, Li S, Li S, et al. High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. Cancer Cell Int. 2021;21(1):493doi: 10.1186/s12935-021-02071-y.
Zhao, Z., Li, S., Li, S., Wang, J., Lin, H., & Fu, W. (2021). High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. Cancer cell international, 21(1), 493. https://doi.org/10.1186/s12935-021-02071-y
Zhao, Zongxian, et al. "High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer." Cancer cell international vol. 21,1 (2021): 493. doi: https://doi.org/10.1186/s12935-021-02071-y
Zhao Z, Li S, Li S, Wang J, Lin H, Fu W. High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. Cancer Cell Int. 2021 Sep 16;21(1):493. doi: 10.1186/s12935-021-02071-y. PMID: 34530820; PMCID: PMC8447617.
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Cancer Cell Int. 2021 Sep 16;21(1):493. doi: 10.1186/s12935-021-02071-y.

High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer.

Cancer cell international

Zongxian Zhao, Shuliang Li, Shilong Li, Jun Wang, Hai Lin, Weihua Fu

Affiliations

  1. Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, China. [email protected].
  2. Department of Gastrointestinal Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shangdong, China. [email protected].
  3. Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, China.
  4. Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, China. [email protected].

PMID: 34530820 PMCID: PMC8447617 DOI: 10.1186/s12935-021-02071-y

Abstract

BACKGROUND: Gastric cancer (GC) is one of the most common and fatal cancers worldwide. Effective biomarkers to aid the early diagnosis of GC, as well as predict the course of disease, are urgently needed. Hence, we explored the role and function of cadherin-6 (CDH6) in the diagnosis and prognosis of gastric cancer.

METHODS: The expression levels of CDH6 in cancerous and normal gastric tissue were analyzed using multiple public databases. Gene set enrichment analysis (GSEA) was performed using The Cancer Genome Atlas (TCGA) dataset. The diagnostic efficiency of CDH6 expression in GC patients was determined through receiver operating characteristic (ROC) curve analysis. The associations between clinical variables and CDH6 expression were evaluated statistically, and the prognostic factors for overall survival were analyzed by univariate and multivariate Cox regression. 44 GC tissue samples, 20 donor-matched adjacent normal tissue samples, and associated detailed clinical information, were collected from the Tianjin Medical University General Hospital. CDH6 expression levels were determined for further validation.

RESULTS: CDH6 was upregulated in GC samples compared to normal gastric tissue. Furthermore, GSEA identified the tricarboxylic acid (TCA) cycle, extracellular matrix (ECM) receptor interaction, glyoxylate and dicarboxylate metabolism, oxidative phosphorylation, and the pentose phosphate pathway as differentially enriched in GC tissue samples. According to the area under the ROC curve (AUC) values (AUC = 0.829 in the TCGA and 0.966 in the GSE54129 dataset), CDH6 expression was associated with high diagnostic efficacy. Patients with high CDH6 levels in their GC tissues had a higher T number (according to the TNM classification) and a worse prognosis than those with low CDH6 expression. Univariate and multivariate Cox regression analysis showed that CDH6 was an independent risk factor for overall survival (univariate: HR = 1.305, P = 0.002, multivariate: HR = 1.481, P < 0.001).

CONCLUSION: CDH6 was upregulated in GC, and high CDH6 expression was indicative of a higher T number and a worse prognosis. Therefore, CDH6 represents a potentially independent molecular biomarker for the diagnostic and prognostic prediction of GC.

© 2021. The Author(s).

Keywords: Cadherin-6; Gastric cancer; Oncogene; Prognosis; Tumor progression

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