Display options
Cite
Olivera C, Mosmann JP, Paira DA, et al. Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples. Sci Rep. 2021;11(1):19924doi: 10.1038/s41598-021-99279-9.
Olivera, C., Mosmann, J. P., Paira, D. A., Molina, R. I., Tissera, A. D., Motrich, R. D., Cuffini, C. G., & Rivero, V. E. (2021). Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples. Scientific reports, 11(1), 19924. https://doi.org/10.1038/s41598-021-99279-9
Olivera, Carolina, et al. "Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples." Scientific reports vol. 11,1 (2021): 19924. doi: https://doi.org/10.1038/s41598-021-99279-9
Olivera C, Mosmann JP, Paira DA, Molina RI, Tissera AD, Motrich RD, Cuffini CG, Rivero VE. Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples. Sci Rep. 2021 Oct 07;11(1):19924. doi: 10.1038/s41598-021-99279-9. PMID: 34620929; PMCID: PMC8497555.
Copy Download .nbib Format: NLM
Share it on

Sci Rep. 2021 Oct 07;11(1):19924. doi: 10.1038/s41598-021-99279-9.

Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples.

Scientific reports

Carolina Olivera, Jessica P Mosmann, Daniela A Paira, Rosa I Molina, Andrea D Tissera, Rubén D Motrich, Cecilia G Cuffini, Virginia E Rivero

Affiliations

  1. Centro de Investigaciones en Bioquímica Clínica E Inmunología, CIBICI-CONICET, Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. Haya de La Torre Y Medina Allende, Ciudad Universitaria, X5016HUA, Córdoba, Argentina.
  2. Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
  3. Instituto de Virología "Dr. José M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
  4. Consejo Nacional de Investigaciones Científicas Y Técnicas (CONICET), Buenos Aires, Argentina.
  5. Laboratorio de Andrología Y Reproducción, Córdoba, Argentina.
  6. Centro de Investigaciones en Bioquímica Clínica E Inmunología, CIBICI-CONICET, Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. Haya de La Torre Y Medina Allende, Ciudad Universitaria, X5016HUA, Córdoba, Argentina. [email protected].
  7. Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. [email protected].

PMID: 34620929 PMCID: PMC8497555 DOI: 10.1038/s41598-021-99279-9

Abstract

The prevalence of HPV infection and its relationship with other sexually transmitted infections was analyzed in a cohort of 117 male partners of infertile couples from Cordoba, Argentina. Semen samples and urethral swabs were obtained and the infection with HPV, Chlamydia trachomatis, HSV1, HSV2, Mycoplasma hominis and Ureaplasma urealyticum was analyzed. A prevalence of HPV infection of 27.4% was found. Interestingly, infections by exclusively low risk HPV genotypes or high/intermediate risk HPV genotypes were present in 64.5% and 22.6% of cases, respectively. Low risk-HPV6 was the most frequently detected genotype. Remarkably, HPV and C. trachomatis infections were significantly associated to each other (OR: 11.55, 95% CI 1.14-117.06). No significant differences in sperm quality were found between HPV-positive and HPV-negative patients indicating that HPV male urogenital infection does not impair sperm quality. Our results show a high prevalence of HPV urogenital infection among male partners of infertile couples, and that HPV and C. trachomatis infections are reciprocal risk factors of their co-infection. Moreover, our results suggest that men constitute a reservoir for continued transmission of C. trachomatis and HPV to women highlighting the need for routine screening for these two pathogens in male partners of infertile couples.

© 2021. The Author(s).

References

  1. J Med Virol. 2017 Sep;89(9):1654-1661 - PubMed
  2. J Reprod Med. 2000 Nov;45(11):907-11 - PubMed
  3. J Infect Dis. 2004 Aug 1;190(3):468-76 - PubMed
  4. Hum Reprod. 2016 Feb;31(2):280-6 - PubMed
  5. Acta Cytol. 2019;63(2):109-117 - PubMed
  6. PLoS One. 2014 Jun 12;9(6):e98862 - PubMed
  7. Fertil Steril. 2019 Jun;111(6):1135-1144 - PubMed
  8. Am J Cancer Res. 2016 Jun 01;6(6):1371-83 - PubMed
  9. J Reprod Infertil. 2020 Jul-Sep;21(3):183-188 - PubMed
  10. Nat Rev Urol. 2014 Dec;11(12):672-87 - PubMed
  11. BJU Int. 2014 Feb;113(2):281-7 - PubMed
  12. Diagn Microbiol Infect Dis. 2013 Dec;77(4):283-6 - PubMed
  13. Hum Reprod. 2019 Feb 1;34(2):209-217 - PubMed
  14. PLoS One. 2015 May 18;10(5):e0126936 - PubMed
  15. J Low Genit Tract Dis. 2011 Jul;15(3):231-4 - PubMed
  16. Hum Reprod. 2014 Apr;29(4):640-51 - PubMed
  17. Int J Fertil Steril. 2019 Jan;12(4):306-309 - PubMed
  18. Int Urol Nephrol. 2020 Jan;52(1):1-8 - PubMed
  19. Biomed Res Int. 2017;2017:4684629 - PubMed
  20. BMC Infect Dis. 2017 Nov 9;17(1):714 - PubMed
  21. Fertil Steril. 1993 Aug;60(2):372-5 - PubMed
  22. Biomed Res Int. 2014;2014:956901 - PubMed
  23. Andrology. 2015 Mar;3(2):163-73 - PubMed
  24. Fertil Steril. 2013 Jan;99(1):125-131.e2 - PubMed
  25. J Androl. 2008 Mar-Apr;29(2):198-206 - PubMed
  26. J Reprod Immunol. 2013 Nov;100(1):20-9 - PubMed
  27. Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1107-14 - PubMed
  28. P R Health Sci J. 2010 Sep;29(3):232-40 - PubMed
  29. J Infect Dis. 2007 Oct 15;196(8):1146-52 - PubMed
  30. Virology. 2004 Jun 20;324(1):17-27 - PubMed
  31. Clin Infect Dis. 2020 May 6;70(10):2161-2167 - PubMed
  32. Hum Reprod. 2006 Jan;21(1):134-7 - PubMed
  33. J Infect Dis. 1994 Nov;170(5):1077-85 - PubMed
  34. J Clin Virol. 2005 Mar;32 Suppl 1:S25-33 - PubMed
  35. Fertil Steril. 2013 Nov;100(5):1236-40 - PubMed
  36. Sci Rep. 2021 Jul 1;11(1):13655 - PubMed
  37. J Infect Dis. 2004 Feb 15;189(4):677-85 - PubMed
  38. Int J Cancer. 2012 Aug 1;131(3):E282-91 - PubMed
  39. Biomed Res Int. 2014;2014:230263 - PubMed
  40. Sci Rep. 2018 Jan 17;8(1):912 - PubMed
  41. Prev Med. 2011 Oct;53 Suppl 1:S3-4 - PubMed
  42. Asian J Androl. 2018 Sep-Oct;20(5):493-497 - PubMed
  43. Andrologia. 2018 Dec;50(11):e13126 - PubMed
  44. Andrologia. 2019 Apr;51(3):e13202 - PubMed
  45. Fertil Steril. 2010 Feb;93(3):802-6 - PubMed
  46. J Infect Chemother. 2011 Aug;17(4):487-92 - PubMed

Publication Types