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Mazzone SB, Yang SK, Keller JA, et al. Modulation of Vagal Sensory Neurons . Front Physiol. 2021;12:744812doi: 10.3389/fphys.2021.744812.
Mazzone, S. B., Yang, S. K., Keller, J. A., Simanauskaite, J., Arikkatt, J., Fogarty, M. J., Moe, A. A. K., Chen, C., Trewella, M. W., Tian, L., Ritchie, M. E., Chua, B. Y., Phipps, S., Short, K. R., & McGovern, A. E. (2021). Modulation of Vagal Sensory Neurons . Frontiers in physiology, 12744812. https://doi.org/10.3389/fphys.2021.744812
Mazzone, Stuart B, et al. "Modulation of Vagal Sensory Neurons ." Frontiers in physiology vol. 12 (2021): 744812. doi: https://doi.org/10.3389/fphys.2021.744812
Mazzone SB, Yang SK, Keller JA, Simanauskaite J, Arikkatt J, Fogarty MJ, Moe AAK, Chen C, Trewella MW, Tian L, Ritchie ME, Chua BY, Phipps S, Short KR, McGovern AE. Modulation of Vagal Sensory Neurons . Front Physiol. 2021 Sep 21;12:744812. doi: 10.3389/fphys.2021.744812. eCollection 2021. PMID: 34621188; PMCID: PMC8490771.
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Front Physiol. 2021 Sep 21;12:744812. doi: 10.3389/fphys.2021.744812. eCollection 2021.

Modulation of Vagal Sensory Neurons .

Frontiers in physiology

Stuart B Mazzone, Seung-Kwon Yang, Jennifer A Keller, Juste Simanauskaite, Jaisy Arikkatt, Matthew J Fogarty, Aung Aung Kywe Moe, Chen Chen, Matthew W Trewella, Luyi Tian, Matthew E Ritchie, Brendan Y Chua, Simon Phipps, Kirsty R Short, Alice E McGovern

Affiliations

  1. Department of Anatomy and Physiology, The University of Melbourne, Parkville, VIC, Australia.
  2. School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
  3. Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  4. The Peter Doherty Institute for Infection and Immunity, Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, Australia.
  5. QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
  6. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.

PMID: 34621188 PMCID: PMC8490771 DOI: 10.3389/fphys.2021.744812

Abstract

Vagal sensory neurons contribute to the symptoms and pathogenesis of inflammatory pulmonary diseases through processes that involve changes to their morphological and functional characteristics. The alarmin high mobility group box-1 (HMGB1) is an early mediator of pulmonary inflammation and can have actions on neurons in a range of inflammatory settings. We hypothesized that HMGB1 can regulate the growth and function of vagal sensory neurons and we set out to investigate this and the mechanisms involved. Culturing primary vagal sensory neurons from wildtype mice in the presence of HMGB1 significantly increased neurite outgrowth, while acute application of HMGB1 to isolated neurons under patch clamp electrophysiological investigation produced inward currents and enhanced action potential firing. Transcriptional analyses revealed the expression of the cognate HMGB1 receptors, Receptor for Advanced Glycation End products (RAGE) and Toll-like Receptor 4 (TLR4), in subsets of vagal sensory neurons. HMGB1-evoked growth and electrophysiological responses were significantly reduced in primary vagal sensory neurons harvested from RAGE deficient mice and completely absent in neurons from RAGE/TLR4 double deficient mice. Immunohistochemical analysis of vagal sensory neurons collected from mice after intranasal infection with murine pneumovirus or influenza A virus (IAV), or after intratracheal administration with the viral mimetic PolyI:C, revealed a significant increase in nuclear-to-cytoplasm translocation of HMGB1 compared to mock-inoculated mice. Neurons cultured from virus infected wildtype mice displayed a significant increase in neurite outgrowth, which was not observed for neurons from virus infected RAGE or RAGE/TLR4 deficient mice. These data suggest that HMGB1 can enhance vagal sensory neuron growth and excitability, acting primarily

Copyright © 2021 Mazzone, Yang, Keller, Simanauskaite, Arikkatt, Fogarty, Moe, Chen, Trewella, Tian, Ritchie, Chua, Phipps, Short and McGovern.

Keywords: hyperinnervation; hypersensitivity; respiratory virus; vagal ganglia; visceral sensory

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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