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Sachdeva M, Lara-Corrales I, Pope E, et al. Outcomes of skin cancers in pediatric solid organ transplant patients: A systematic review. Pediatr Transplant. 2021;e14146doi: 10.1111/petr.14146.
Sachdeva, M., Lara-Corrales, I., Pope, E., Chan, A. W., Parekh, R. S., Kitchlu, A., & Sibbald, C. (2021). Outcomes of skin cancers in pediatric solid organ transplant patients: A systematic review. Pediatric transplantation, e14146. https://doi.org/10.1111/petr.14146
Sachdeva, Muskaan, et al. "Outcomes of skin cancers in pediatric solid organ transplant patients: A systematic review." Pediatric transplantation vol. (2021): e14146. doi: https://doi.org/10.1111/petr.14146
Sachdeva M, Lara-Corrales I, Pope E, Chan AW, Parekh RS, Kitchlu A, Sibbald C. Outcomes of skin cancers in pediatric solid organ transplant patients: A systematic review. Pediatr Transplant. 2021 Sep 25;e14146. doi: 10.1111/petr.14146. Epub 2021 Sep 25. PMID: 34562053.
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Pediatr Transplant. 2021 Sep 25;e14146. doi: 10.1111/petr.14146. Epub 2021 Sep 25.

Outcomes of skin cancers in pediatric solid organ transplant patients: A systematic review.

Pediatric transplantation

Muskaan Sachdeva, Irene Lara-Corrales, Elena Pope, An-Wen Chan, Rulan S Parekh, Abhijat Kitchlu, Cathryn Sibbald

Affiliations

  1. Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  2. Division of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  3. Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, ON, Canada.
  4. Division of Pediatric Nephrology, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.
  5. Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.

PMID: 34562053 DOI: 10.1111/petr.14146

Abstract

BACKGROUND: The most frequently reported malignancies after solid organ transplant are cutaneous, but data on the risk in pediatric populations varies across studies.

OBJECTIVES: To perform a systematic review including reported features and outcomes of skin cancers in pediatric solid organ transplant recipients.

METHODS: EMBASE and MEDLINE were systematically searched (Prospero CRD42020201659).

RESULTS: The review summarizes data from 20 studies on 337 patients, with a median age ranging from 15.0 to 19.5 years as reported in 4 studies, who developed skin malignancies after pediatric solid organ transplantation. Median ages at transplant and skin cancer diagnosis ranged from 1.5 to 17.0 years and 15.3 to 33.5 years, respectively. Squamous cell carcinoma (SCC) was most commonly reported (218 cases), followed by basal cell carcinoma (BCC) (91 cases), melanoma (18 cases), and unspecified keratinocyte carcinomas (2 cases). The median latency period between transplantation and cancer diagnosis ranged from 2.2 to 21.0 years. Overall, 4 studies reported 17 cases of metastasis in total, and recurrence was reported in one case. Six deaths were reported in one study related to SCC and melanoma metastases. The incidence rate of skin cancer after pediatric transplantation per 100 person-years of follow-up was 2.1 based on 5 studies.

CONCLUSION: The most frequent post-transplant malignancy in pediatric organ transplant recipients was SCC.

© 2021 Wiley Periodicals LLC.

Keywords: keratinocyte carcinoma; melanoma; pediatric; skin cancer; transplant

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