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Lavit E, Aldea M, Piperno-Neumann S, et al. Treatment of 120 adult osteosarcoma patients with metachronous and synchronous metastases: A retrospective series of the French Sarcoma Group. Int J Cancer. 2021;doi: 10.1002/ijc.33823.
Lavit, E., Aldea, M., Piperno-Neumann, S., Firmin, N., Italiano, A., Isambert, N., Kurtz, J. E., Delcambre, C., Lebrun, V., Soibinet-Oudot, P., Chevreau, C., Bompas, E., Le Maignan, C., Boudou-Rouquette, P., Le Cesne, A., Mancini, J., Blay, J. Y., & Duffaud, F. (2021). Treatment of 120 adult osteosarcoma patients with metachronous and synchronous metastases: A retrospective series of the French Sarcoma Group. International journal of cancer, . https://doi.org/10.1002/ijc.33823
Lavit, Elise, et al. "Treatment of 120 adult osteosarcoma patients with metachronous and synchronous metastases: A retrospective series of the French Sarcoma Group." International journal of cancer vol. (2021). doi: https://doi.org/10.1002/ijc.33823
Lavit E, Aldea M, Piperno-Neumann S, Firmin N, Italiano A, Isambert N, Kurtz JE, Delcambre C, Lebrun V, Soibinet-Oudot P, Chevreau C, Bompas E, Le Maignan C, Boudou-Rouquette P, Le Cesne A, Mancini J, Blay JY, Duffaud F. Treatment of 120 adult osteosarcoma patients with metachronous and synchronous metastases: A retrospective series of the French Sarcoma Group. Int J Cancer. 2021 Sep 25; doi: 10.1002/ijc.33823. Epub 2021 Sep 25. PMID: 34562271.
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Int J Cancer. 2021 Sep 25; doi: 10.1002/ijc.33823. Epub 2021 Sep 25.

Treatment of 120 adult osteosarcoma patients with metachronous and synchronous metastases: A retrospective series of the French Sarcoma Group.

International journal of cancer

Elise Lavit, Mihaela Aldea, Sophie Piperno-Neumann, Nelly Firmin, Antoine Italiano, Nicolas Isambert, Jean-Emmanuel Kurtz, Corinne Delcambre, Valérie Lebrun, Pauline Soibinet-Oudot, Christine Chevreau, Emmanuelle Bompas, Christine Le Maignan, Pascaline Boudou-Rouquette, Axel Le Cesne, Julien Mancini, Jean-Yves Blay, Florence Duffaud

Affiliations

  1. Department of Oncology, Hôpital La Timone, Marseille, France.
  2. Institut Gustave Roussy, Villejuif, France.
  3. Institut Curie, Paris, France.
  4. Institut du Cancer de Montpellier, Montpellier, France.
  5. Institut Bergonie, Bordeaux, France.
  6. Centre Georges-François Leclerc, Dijon, France.
  7. Department of Onco-Hematology, University Hospital Strasbourg, Strasbourg, France.
  8. Centre François Baclesse, Caen, France.
  9. Department of Oncology, University Hospital Dupuytren, Limoges, France.
  10. Institut Jean Godinot, Reims, France.
  11. Institut Claudius Regaud, Toulouse, France.
  12. Institut de Cancérologie de l'Ouest, Nantes, France.
  13. Hôpital Saint-Louis AP-HP, Paris, France.
  14. Department of Oncology, Hôpital Cochin, Paris, France.
  15. Aix Marseille University, Inserm, IRD, SESSTIM, Marseille, France.
  16. Centre Léon Bérard, Lyon, France.

PMID: 34562271 DOI: 10.1002/ijc.33823

Abstract

Treatment options for metastatic osteosarcomas are scarce. Following failure of standard first line therapy, patients who relapse present a challenging treatment dilemma, and have a poor prognosis. Surgical removal of all metastases is essential. A retrospective analysis of patients with metastatic osteosarcomas was conducted in 15 French Sarcoma Group centers. From January 2009 to December 2018, we identified 120 adult patients; 36 with synchronous and 84 with metachronous metastases with 74 males and 46 females. Mean age was 30 years (18-53). Metastatic sites were lung, bone and other in 91, 11 and 24 patients, respectively. Mean time to first metachronous metastases was 22 months (4-97). All patients except 13 (10.8%) with metachronous metastases received a first line systemic treatment for relapse, and 39 patients (32.5%) were included in a clinical trial. Eighty-one patients (67.5%) had local treatment of distant metastases. Median progression free survival (PFS) and overall survival (OS) were 5.5 (95% CI 4.6-6.4) and 20.5 months (95% CI 13.2-27.7) respectively for the overall group. In multivariate analysis, more than five metastases, time to first metastases <24 months, were statistically significant negative prognostic factors for OS and PFS (P = .002, ≤.001 and P = .006, ≤.001, respectively). Surgery of metastases was associated with better prognosis on OS and PFS (P = .001 and .037, respectively). The presence of bone metastases was a negative prognostic factor on OS but not on PFS (P = .021). In reference sarcoma centers, relapsed osteosarcoma patients with more than one metastasis commonly receive more than one line of systemic therapy, and are included in clinical trial if available.

© 2021 UICC.

Keywords: metastatic osteosarcomas; prognosis; treatment

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