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Palaiodimou L, Lioutas VA, Lambadiari V, et al. Glycemic variability of acute stroke patients and clinical outcomes: a continuous glucose monitoring study. Ther Adv Neurol Disord. 2021;14:17562864211045876doi: 10.1177/17562864211045876.
Palaiodimou, L., Lioutas, V. A., Lambadiari, V., Theodorou, A., Themistocleous, M., Aponte, L., Papagiannopoulou, G., Foska, A., Bakola, E., Quispe, R., Mendez, L., Selim, M., Novak, V., Tzavellas, E., Halvatsiotis, P., Voumvourakis, K., & Tsivgoulis, G. (2021). Glycemic variability of acute stroke patients and clinical outcomes: a continuous glucose monitoring study. Therapeutic advances in neurological disorders, 1417562864211045876. https://doi.org/10.1177/17562864211045876
Palaiodimou, Lina, et al. "Glycemic variability of acute stroke patients and clinical outcomes: a continuous glucose monitoring study." Therapeutic advances in neurological disorders vol. 14 (2021): 17562864211045876. doi: https://doi.org/10.1177/17562864211045876
Palaiodimou L, Lioutas VA, Lambadiari V, Theodorou A, Themistocleous M, Aponte L, Papagiannopoulou G, Foska A, Bakola E, Quispe R, Mendez L, Selim M, Novak V, Tzavellas E, Halvatsiotis P, Voumvourakis K, Tsivgoulis G. Glycemic variability of acute stroke patients and clinical outcomes: a continuous glucose monitoring study. Ther Adv Neurol Disord. 2021 Sep 22;14:17562864211045876. doi: 10.1177/17562864211045876. eCollection 2021. PMID: 34589140; PMCID: PMC8474316.
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Ther Adv Neurol Disord. 2021 Sep 22;14:17562864211045876. doi: 10.1177/17562864211045876. eCollection 2021.

Glycemic variability of acute stroke patients and clinical outcomes: a continuous glucose monitoring study.

Therapeutic advances in neurological disorders

Lina Palaiodimou, Vasileios-Arsenios Lioutas, Vaia Lambadiari, Aikaterini Theodorou, Marios Themistocleous, Laura Aponte, Georgia Papagiannopoulou, Aikaterini Foska, Eleni Bakola, Rodrigo Quispe, Laura Mendez, Magdy Selim, Vera Novak, Elias Tzavellas, Panagiotis Halvatsiotis, Konstantinos Voumvourakis, Georgios Tsivgoulis

Affiliations

  1. Second Department of Neurology, School of Medicine, University General Hospital 'Attikon', National and Kapodistrian University of Athens, Athens, Greece.
  2. Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  3. Second Department of Internal Medicine-Propaedeutic and Diabetes Center, Medical School, University General Hospital 'Attikon', National and Kapodistrian University of Athens, Athens, Greece.
  4. Department of Neurosurgery, Pediatric Hospital of Athens, Agia Sophia, Athens, Greece.
  5. First Department of Psychiatry, Aiginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  6. Second Department of Neurology, School of Medicine, University General Hospital 'Attikon', National and Kapodistrian University of Athens, Rimini 1, Chaidari, Athens 12462, Greece.

PMID: 34589140 PMCID: PMC8474316 DOI: 10.1177/17562864211045876

Abstract

INTRODUCTION: Glycemic variability (GV) has been associated with worse prognosis in critically ill patients. We sought to evaluate the potential association between GV indices and clinical outcomes in acute stroke patients.

METHODS: Consecutive diabetic and nondiabetic, acute ischemic or hemorrhagic stroke patients underwent regular, standard-of-care finger-prick measurements and continuous glucose monitoring (CGM) for up to 96 h. Thirteen GV indices were obtained from CGM data. Clinical outcomes during hospitalization and follow-up period (90 days) were recorded. Hypoglycemic episodes disclosed by CGM but missed by finger-prick measurements were also documented.

RESULTS: A total of 62 acute stroke patients [48 ischemic and 14 hemorrhagic, median NIHSS score: 9 (IQR: 3-16) points, mean age: 65 ± 10 years, women: 47%, nondiabetic: 79%] were enrolled. GV expressed by higher mean absolute glucose (MAG) values was associated with a lower likelihood of neurological improvement during hospitalization before and after adjusting for potential confounders (OR: 0.135, 95% CI: 0.024-0.751,

CONCLUSIONS: Greater GV of acute stroke patients may be related to lower odds of neurological improvement during hospitalization. No association was disclosed between GV indices and 3-month clinical outcomes.

© The Author(s), 2021.

Keywords: acute stroke; clinical outcomes; continuous glucose monitoring; glycemic variability; hypoglycemic episodes; neurological improvement

Conflict of interest statement

Conflict of interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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