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May SM, Chiang E, Reyes A, et al. Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study. Brain Behav Immun Health. 2021;16:100299doi: 10.1016/j.bbih.2021.100299.
May, S. M., Chiang, E., Reyes, A., Martir, G., Patel, A., Karmali, S., Patel, S., West, S., Del Arroyo, A. G., Gourine, A. V., & Ackland, G. L. (2021). Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study. Brain, behavior, & immunity - health, 16100299. https://doi.org/10.1016/j.bbih.2021.100299
May, Shaun M, et al. "Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study." Brain, behavior, & immunity - health vol. 16 (2021): 100299. doi: https://doi.org/10.1016/j.bbih.2021.100299
May SM, Chiang E, Reyes A, Martir G, Patel A, Karmali S, Patel S, West S, Del Arroyo AG, Gourine AV, Ackland GL. Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study. Brain Behav Immun Health. 2021 Jul 15;16:100299. doi: 10.1016/j.bbih.2021.100299. eCollection 2021 Oct. PMID: 34589791; PMCID: PMC8417773.
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Brain Behav Immun Health. 2021 Jul 15;16:100299. doi: 10.1016/j.bbih.2021.100299. eCollection 2021 Oct.

Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study.

Brain, behavior, & immunity - health

Shaun M May, Eric Chiang, Anna Reyes, Gladys Martir, Amour Patel, Shamir Karmali, Sanjiv Patel, Simeon West, Ana Gutierrez Del Arroyo, Alexander V Gourine, Gareth L Ackland

Affiliations

  1. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK.
  2. University College Hospital NHS Trust, London, UK.
  3. Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, UK.

PMID: 34589791 PMCID: PMC8417773 DOI: 10.1016/j.bbih.2021.100299

Abstract

Experimental animal studies on the mechanisms of remote ischaemic conditioning (RIC)-induced cardioprotection against ischaemia/reperfusion injury demonstrate involvement of both neuronal and humoral pathways. Autonomic parasympathetic (vagal) pathways confer organ protection through both direct innervation and/or immunomodulation, but evidence in humans is lacking. During acute inflammation, vagal release of acetylcholine suppresses CD11b expression, a critical β2-integrin regulating neutrophil adhesion to the endothelium and transmigration to sites of injury. Here, we tested the hypothesis that RIC recruits vagal activity in humans and has an anti-inflammatory effect by reducing neutrophil CD11b expression. Participants (age:50 ​± ​19 years; 53% female) underwent ultrasound-guided injection of local anaesthetic within the brachial plexus before applying 3 ​× ​8 min cycles of brachial artery occlusion using a blood pressure cuff (RIC

© 2021 The Author(s).

Keywords: Autonomic nervous system; Heart rate variability; Inflammation; Neutrophil; Remote ischaemic conditioning; Vagus

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