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Pattyn J, Hendrickx G, Vorsters A, et al. Hepatitis B Vaccines. J Infect Dis. 2021;224:S343-S351doi: 10.1093/infdis/jiaa668.
Pattyn, J., Hendrickx, G., Vorsters, A., & Van Damme, P. (2021). Hepatitis B Vaccines. The Journal of infectious diseases, 224S343-S351. https://doi.org/10.1093/infdis/jiaa668
Pattyn, Jade, et al. "Hepatitis B Vaccines." The Journal of infectious diseases vol. 224 (2021): S343-S351. doi: https://doi.org/10.1093/infdis/jiaa668
Pattyn J, Hendrickx G, Vorsters A, Van Damme P. Hepatitis B Vaccines. J Infect Dis. 2021 Sep 30;224:S343-S351. doi: 10.1093/infdis/jiaa668. PMID: 34590138; PMCID: PMC8482019.
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J Infect Dis. 2021 Sep 30;224:S343-S351. doi: 10.1093/infdis/jiaa668.

Hepatitis B Vaccines.

The Journal of infectious diseases

Jade Pattyn, Greet Hendrickx, Alex Vorsters, Pierre Van Damme

Affiliations

  1. Centre for the Evaluation of Vaccination, University of Antwerp, Antwerp, Belgium.

PMID: 34590138 PMCID: PMC8482019 DOI: 10.1093/infdis/jiaa668

Abstract

Hepatitis B is caused by the hepatitis B virus (HBV), which infects the liver and may lead to chronic liver disease, including cirrhosis and hepatocellular carcinoma. HBV represents a worldwide public health problem, causing major morbidity and mortality. Affordable, safe, and effective, hepatitis B vaccines are the best tools we have to control and prevent hepatitis B. In 2019, coverage of 3 doses of the hepatitis B vaccine reached 85% worldwide compared to around 30% in 2000. The effective implementation of hepatitis B vaccination programs has resulted in a substantial decrease in the HBV carrier rate and hepatitis B-related morbidity and mortality. This article summarizes the great triumphs of the hepatitis B vaccine, the first anticancer and virus-like-particle-based vaccine. In addition, existing unresolved issues and future perspectives on hepatitis B vaccination required for global prevention of HBV infection are discussed.

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

Keywords: hepatitis B; hepatitis B vaccination; hepatitis B virus

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