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Toxins (Basel). 2021 Sep 10;13(9). doi: 10.3390/toxins13090642.

A Combined Transcriptomics and Proteomics Approach Reveals the Differences in the Predatory and Defensive Venoms of the Molluscivorous Cone Snail .

Toxins

Samuel Abalde, Sébastien Dutertre, Rafael Zardoya

Affiliations

  1. Departamento de Biodiversidad y Biología Evolutiva, Museo Nacional de Ciencias Naturales (MNCN-CSIC), José Gutiérrez Abascal 2, 28006 Madrid, Spain.
  2. Department of Zoology, Swedish Museum of Natural History, Frescativägen 40, 114 18 Stockholm, Sweden.
  3. IBMM, Université de Montpellier CNRS, ENSCM, 34095 Montpellier, France.

PMID: 34564647 PMCID: PMC8472973 DOI: 10.3390/toxins13090642

Abstract

Venoms are complex mixtures of proteins that have evolved repeatedly in the animal kingdom. Cone snail venoms represent one of the best studied venom systems. In nature, this venom can be dynamically adjusted depending on its final purpose, whether to deter predators or hunt prey. Here, the transcriptome of the venom gland and the proteomes of the predation-evoked and defensive venoms of the molluscivorous cone snail

Keywords: Conidae; Cylinder ammiralis; cono-insulin; conotoxin; proteome; transcriptome

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