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Oeztuerk OF, Pigoni A, Wenzel J, et al. The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study. Eur Arch Psychiatry Clin Neurosci. 2021;doi: 10.1007/s00406-021-01327-y.
Oeztuerk, O. F., Pigoni, A., Wenzel, J., Haas, S. S., Popovic, D., Ruef, A., Dwyer, D. B., Kambeitz-Ilankovic, L., Ruhrmann, S., Chisholm, K., Lalousis, P., Griffiths, S. L., Lichtenstein, T., Rosen, M., Kambeitz, J., Schultze-Lutter, F., Liddle, P., Upthegrove, R., Salokangas, R. K. R., Pantelis, C., Meisenzahl, E., Wood, S. J., Brambilla, P., Borgwardt, S., Falkai, P., Antonucci, L. A., Koutsouleris, N. (2021). The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study. European archives of psychiatry and clinical neuroscience, . https://doi.org/10.1007/s00406-021-01327-y
Oeztuerk, Oemer Faruk, et al. "The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study." European archives of psychiatry and clinical neuroscience vol. (2021). doi: https://doi.org/10.1007/s00406-021-01327-y
Oeztuerk OF, Pigoni A, Wenzel J, Haas SS, Popovic D, Ruef A, Dwyer DB, Kambeitz-Ilankovic L, Ruhrmann S, Chisholm K, Lalousis P, Griffiths SL, Lichtenstein T, Rosen M, Kambeitz J, Schultze-Lutter F, Liddle P, Upthegrove R, Salokangas RKR, Pantelis C, Meisenzahl E, Wood SJ, Brambilla P, Borgwardt S, Falkai P, Antonucci LA, Koutsouleris N. The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study. Eur Arch Psychiatry Clin Neurosci. 2021 Sep 17; doi: 10.1007/s00406-021-01327-y. Epub 2021 Sep 17. PMID: 34535813.
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Eur Arch Psychiatry Clin Neurosci. 2021 Sep 17; doi: 10.1007/s00406-021-01327-y. Epub 2021 Sep 17.

The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study.

European archives of psychiatry and clinical neuroscience

Oemer Faruk Oeztuerk, Alessandro Pigoni, Julian Wenzel, Shalaila S Haas, David Popovic, Anne Ruef, Dominic B Dwyer, Lana Kambeitz-Ilankovic, Stephan Ruhrmann, Katharine Chisholm, Paris Lalousis, Sian Lowri Griffiths, Theresa Lichtenstein, Marlene Rosen, Joseph Kambeitz, Frauke Schultze-Lutter, Peter Liddle, Rachel Upthegrove, Raimo K R Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt, Peter Falkai, Linda A Antonucci, Nikolaos Koutsouleris,

Affiliations

  1. Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Nussbaumstr. 7, 80336, Munich, Germany. [email protected].
  2. International Max Planck Research School for Translational Psychiatry, Munich, Germany. [email protected].
  3. Max Planck Institute for Psychiatry, Munich, Germany. [email protected].
  4. MoMiLab Research Unit, IMT School for Advanced Studies Lucca, Lucca, Italy.
  5. Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
  6. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
  7. Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Nussbaumstr. 7, 80336, Munich, Germany.
  8. International Max Planck Research School for Translational Psychiatry, Munich, Germany.
  9. School of Psychology, Aston University, Birmingham, UK.
  10. Institute for Mental Health, University of Birmingham, Birmingham, UK.
  11. Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  12. Division of Psychiatry and Applied Psychology, Institute of Mental Health, University of Nottingham, Nottingham, UK.
  13. Department of Psychiatry, University of Turku, Turku, Finland.
  14. Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia.
  15. Melbourne Health, Melbourne, Australia.
  16. School of Psychology, University of Birmingham, Birmingham, UK.
  17. Orygen, The National Centre of Excellence for Youth Mental Health, Melbourne, Australia.
  18. Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  19. Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
  20. Department of Psychiatry, University Psychiatric Clinic, Psychiatric University Hospital, University of Basel, Basel, Switzerland.
  21. Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari "Aldo Moro", Bari, Italy.
  22. Department of Education, Psychology and Communication Science, University of Bari "Aldo Moro", Bari, Italy.
  23. Max Planck Institute for Psychiatry, Munich, Germany.
  24. Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

PMID: 34535813 DOI: 10.1007/s00406-021-01327-y

Abstract

BACKGROUND: Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition.

METHODS: 279 patients with ROP were recruited as part of the multi-site European PRONIA study (Personalised Prognostic Tools for Early Psychosis Management; www.pronia.eu). Five FTD-related symptoms (conceptual disorganization, poverty of content of speech, difficulty in abstract thinking, increased latency of response and poverty of speech) were assessed with Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS).

RESULTS: The results with two patient subgroups showing different levels of FTD were the most stable and generalizable clustering solution (predicted clustering strength value = 0.86). FTD-High subgroup had lower scores in social (p

CONCLUSIONS: Clustering techniques allowed us to identify patients with more pronounced FTD showing more severe deficits in functioning and neurocognition, thus suggesting that FTD may be a relevant marker of illness severity in the early psychosis pathway.

© 2021. The Author(s).

Keywords: Clustering; Early psychosis; Formal thought disorder; Functioning; Neurocognition

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