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Körber N, Pohl L, Weinberger B, et al. Hepatitis B Vaccine Non-Responders Show Higher Frequencies of CD24. Front Immunol. 2021;12:713351doi: 10.3389/fimmu.2021.713351.
Körber, N., Pohl, L., Weinberger, B., Grubeck-Loebenstein, B., Wawer, A., Knolle, P. A., Roggendorf, H., Protzer, U., & Bauer, T. (2021). Hepatitis B Vaccine Non-Responders Show Higher Frequencies of CD24. Frontiers in immunology, 12713351. https://doi.org/10.3389/fimmu.2021.713351
Körber, Nina, et al. "Hepatitis B Vaccine Non-Responders Show Higher Frequencies of CD24." Frontiers in immunology vol. 12 (2021): 713351. doi: https://doi.org/10.3389/fimmu.2021.713351
Körber N, Pohl L, Weinberger B, Grubeck-Loebenstein B, Wawer A, Knolle PA, Roggendorf H, Protzer U, Bauer T. Hepatitis B Vaccine Non-Responders Show Higher Frequencies of CD24. Front Immunol. 2021 Sep 10;12:713351. doi: 10.3389/fimmu.2021.713351. eCollection 2021. PMID: 34566969; PMCID: PMC8461011.
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Front Immunol. 2021 Sep 10;12:713351. doi: 10.3389/fimmu.2021.713351. eCollection 2021.

Hepatitis B Vaccine Non-Responders Show Higher Frequencies of CD24.

Frontiers in immunology

Nina Körber, Laureen Pohl, Birgit Weinberger, Beatrix Grubeck-Loebenstein, Andrea Wawer, Percy A Knolle, Hedwig Roggendorf, Ulrike Protzer, Tanja Bauer

Affiliations

  1. Institute of Virology, Helmholtz Zentrum München, Munich, Germany.
  2. German Center for Infection Research (DZIF), Munich, Germany.
  3. Institute for Biomedical Aging Research, Universität Innsbruck, Innsbruck, Austria.
  4. Occupational Health Unit, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
  5. Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
  6. Institute of Virology, School of Medicine, Technical University of Munich (TUM), Munich, Germany.

PMID: 34566969 PMCID: PMC8461011 DOI: 10.3389/fimmu.2021.713351

Abstract

BACKGROUND: The cellular mechanisms involved in the lack of protective antibody response after hepatitis B vaccination are still rather unclear. Regulatory B cells (Breg) known as modulators of B-and T-cell responses may contribute to poor vaccine responsiveness. The current study aimed to investigate the role of regulatory B cells (Breg) in hepatitis B vaccine non-responsiveness after immunization with second- or third-generation hepatitis B vaccines.

METHOD: We performed comparative phenotypic and frequency analysis of Breg subsets (CD24

RESULTS: Flow cytometry-based analyses revealed elevated frequencies of CD24

CONCLUSION: Here we report significantly higher frequencies of CD24

Copyright © 2021 Körber, Pohl, Weinberger, Grubeck-Loebenstein, Wawer, Knolle, Roggendorf, Protzer and Bauer.

Keywords: B10+ cells; IL-10 expression; hepatitis B vaccination; regulatory B cells; vaccine non-responsiveness

Conflict of interest statement

UP received funding for the project from the Helmholtz Association in context of the iMed initiative and the Helmholtz-Alberta-Initiative in Infectious Disease Research. UP serves as scientific adviso

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