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Dai X, Lv X, Thompson EW, et al. Histone lactylation: epigenetic mark of glycolytic switch. Trends Genet. 2021;doi: 10.1016/j.tig.2021.09.009.
Dai, X., Lv, X., Thompson, E. W., & Ostrikov, K. K. (2021). Histone lactylation: epigenetic mark of glycolytic switch. Trends in genetics : TIG, . https://doi.org/10.1016/j.tig.2021.09.009
Dai, Xiaofeng, et al. "Histone lactylation: epigenetic mark of glycolytic switch." Trends in genetics : TIG vol. (2021). doi: https://doi.org/10.1016/j.tig.2021.09.009
Dai X, Lv X, Thompson EW, Ostrikov KK. Histone lactylation: epigenetic mark of glycolytic switch. Trends Genet. 2021 Oct 06; doi: 10.1016/j.tig.2021.09.009. Epub 2021 Oct 06. PMID: 34627643.
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Trends Genet. 2021 Oct 06; doi: 10.1016/j.tig.2021.09.009. Epub 2021 Oct 06.

Histone lactylation: epigenetic mark of glycolytic switch.

Trends in genetics : TIG

Xiaofeng Dai, Xinyu Lv, Erik W Thompson, Kostya Ken Ostrikov

Affiliations

  1. Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected].
  2. Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
  3. Queensland University of Technology, School of Biomedical Sciences, Faculty of Health, Brisbane 4059, Australia; Translational Research Institute, Woolloongabba, QLD 4102, Australia.
  4. Queensland University of Technology, School of Chemistry and Physics, Faculty of Science, Brisbane, QLD 4059, Australia.

PMID: 34627643 DOI: 10.1016/j.tig.2021.09.009

Abstract

Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel therapeutic opportunities against cancers.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: acetylation; epigenetic mark; glycolysis switch; lactylation

Conflict of interest statement

Declaration of interests The authors declare no interests.

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