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Rinaldi I, Prasetyawaty F, Fazlines S, et al. Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review. Case Rep Med. 2021;2021:5554664doi: 10.1155/2021/5554664.
Rinaldi, I., Prasetyawaty, F., Fazlines, S., Winston, K., Samudera Nurrobi, Y. A., Leoni, J., Restu Tulus Maha, I. H., Wicaksono, S., Wicaksono, A. Y., Aslani, A. O., & Ikhsani, R. (2021). Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review. Case reports in medicine, 20215554664. https://doi.org/10.1155/2021/5554664
Rinaldi, Ikhwan, et al. "Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review." Case reports in medicine vol. 2021 (2021): 5554664. doi: https://doi.org/10.1155/2021/5554664
Rinaldi I, Prasetyawaty F, Fazlines S, Winston K, Samudera Nurrobi YA, Leoni J, Restu Tulus Maha IH, Wicaksono S, Wicaksono AY, Aslani AO, Ikhsani R. Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review. Case Rep Med. 2021 Sep 14;2021:5554664. doi: 10.1155/2021/5554664. eCollection 2021. PMID: 34567128; PMCID: PMC8457949.
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Case Rep Med. 2021 Sep 14;2021:5554664. doi: 10.1155/2021/5554664. eCollection 2021.

Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review.

Case reports in medicine

Ikhwan Rinaldi, Findy Prasetyawaty, Siti Fazlines, Kevin Winston, Yusuf Aji Samudera Nurrobi, Jessica Leoni, Ilham Hidayat Restu Tulus Maha, Satrio Wicaksono, Abdillah Yasir Wicaksono, Averina Octaxena Aslani, Rizkania Ikhsani

Affiliations

  1. Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  2. Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  3. Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

PMID: 34567128 PMCID: PMC8457949 DOI: 10.1155/2021/5554664

Abstract

BACKGROUND: Acquired hemophilia A (AHA) is a potentially life-threatening autoimmune hemostatic disorder where autoantibodies that disrupt the functions of factor VIII (FVIII) are present in the circulation. The early diagnosis of AHA is difficult since the symptoms of AHA differ from those of congenital hemophilia A. Furthermore, the management of AHA is also more complex due to the presence of autoantibodies against FVIII (FVIII inhibitors). Here, we present three case reports and conduct a literature review of AHA with the aim to increase awareness and knowledge regarding the diagnosis and treatment of AHA.

CONCLUSION: AHA can be suspected in patients presenting with symptoms of bruises without hemarthrosis and without the history of bleeding. Isolated aPTT elevation with normal PT should raise high suspicion of AHA. The presence of FVIII inhibitors can help to confirm the diagnosis of AHA. Treatment consists of factor VIII transfusion and corticosteroid therapy. Bypassing agents are recommended as an alternative to FVIII transfusion.

Copyright © 2021 Ikhwan Rinaldi et al.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

  1. Hematology Am Soc Hematol Educ Program. 2006;:432-7 - PubMed
  2. Haemophilia. 2020 Aug;26 Suppl 6:1-158 - PubMed
  3. Cureus. 2019 Aug 20;11(8):e5442 - PubMed
  4. J Thromb Haemost. 2012 Apr;10(4):622-31 - PubMed
  5. Ginekol Pol. 2019;90(6):353-364 - PubMed
  6. J Thromb Haemost. 2020 Jan;18(1):36-43 - PubMed
  7. Arterioscler Thromb Vasc Biol. 2000 Dec;20(12):2689-95 - PubMed
  8. Haemophilia. 2017 Jan;23(1):25-32 - PubMed
  9. BMC Res Notes. 2010 Jun 07;3:161 - PubMed
  10. Anesth Pain Med. 2013 Dec 27;4(1):e11906 - PubMed
  11. Blood. 2015 Feb 12;125(7):1091-7 - PubMed
  12. J Blood Med. 2015 May 08;6:143-50 - PubMed
  13. Blood Coagul Fibrinolysis. 2009 Oct;20(7):517-23 - PubMed
  14. Int J Lab Hematol. 2019 Feb;41(1):80-86 - PubMed
  15. Transfus Apher Sci. 2018 Dec;57(6):717-720 - PubMed
  16. Br J Haematol. 2013 Sep;162(6):758-73 - PubMed
  17. Haemophilia. 2015 May;21(3):330-7 - PubMed
  18. Methods Mol Biol. 2013;992:321-33 - PubMed
  19. Haemophilia. 2015 Mar;21(2):162-70 - PubMed
  20. Haemophilia. 2012 Jul;18(4):544-9 - PubMed
  21. Semin Thromb Hemost. 2013 Apr;39(3):283-90 - PubMed
  22. Blood Transfus. 2015 Jul;13(3):498-513 - PubMed
  23. Semin Thromb Hemost. 2014 Oct;40(7):803-11 - PubMed
  24. Am J Hematol. 2017 Jul;92(7):695-705 - PubMed
  25. Semin Thromb Hemost. 2009 Nov;35(8):769-77 - PubMed
  26. Thromb Haemost. 2017 Dec;117(12):2267-2273 - PubMed
  27. Haemophilia. 2014 May;20(3):369-75 - PubMed
  28. Am J Hematol. 2005 Sep;80(1):55-63 - PubMed
  29. J Thromb Haemost. 2012 Aug;10(8):1478-85 - PubMed
  30. Autoimmun Rev. 2011 Apr;10(6):311-6 - PubMed
  31. Blood. 2012 Jul 5;120(1):39-46 - PubMed
  32. Br J Haematol. 2003 Apr;121(1):21-35 - PubMed
  33. Haematologica. 2020 Jul;105(7):1791-1801 - PubMed
  34. Blood Transfus. 2011 Oct;9(4):377-82 - PubMed
  35. Blood. 2012 Jul 5;120(1):47-55 - PubMed
  36. Haematologica. 2000 Oct;85(10 Suppl):64-8 - PubMed
  37. Br J Haematol. 2004 Jan;124(1):86-90 - PubMed
  38. Blood. 2007 Mar 1;109(5):1870-7 - PubMed
  39. J Formos Med Assoc. 2015 Apr;114(4):321-7 - PubMed
  40. J Thromb Haemost. 2007 Dec;5(12):2408-14 - PubMed

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