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Zegarra-Valdivia JA, Chaves-Coira I, Fernandez de Sevilla ME, et al. Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse. Front Aging Neurosci. 2021;13:682388doi: 10.3389/fnagi.2021.682388.
Zegarra-Valdivia, J. A., Chaves-Coira, I., Fernandez de Sevilla, M. E., Martinez-Rachadell, L., Esparza, J., Torres-Aleman, I., & Nuñez, A. (2021). Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse. Frontiers in aging neuroscience, 13682388. https://doi.org/10.3389/fnagi.2021.682388
Zegarra-Valdivia, Jonathan A, et al. "Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse." Frontiers in aging neuroscience vol. 13 (2021): 682388. doi: https://doi.org/10.3389/fnagi.2021.682388
Zegarra-Valdivia JA, Chaves-Coira I, Fernandez de Sevilla ME, Martinez-Rachadell L, Esparza J, Torres-Aleman I, Nuñez A. Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse. Front Aging Neurosci. 2021 Sep 01;13:682388. doi: 10.3389/fnagi.2021.682388. eCollection 2021. PMID: 34539376; PMCID: PMC8442768.
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Front Aging Neurosci. 2021 Sep 01;13:682388. doi: 10.3389/fnagi.2021.682388. eCollection 2021.

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse.

Frontiers in aging neuroscience

Jonathan A Zegarra-Valdivia, Irene Chaves-Coira, Maria Estrella Fernandez de Sevilla, Laura Martinez-Rachadell, Julio Esparza, Ignacio Torres-Aleman, Angel Nuñez

Affiliations

  1. Cajal Institute (CSIC), Madrid, Spain.
  2. CIBERNED, Madrid, Spain.
  3. Universidad Nacional de San Agustín de Arequipa, Arequipa, Peru.
  4. Achucarro Basque Center for Neuroscience, Leioa, Spain.
  5. Department of Anatomy, Histology and Neurosciences, Universidad Autónoma de Madrid, Madrid, Spain.

PMID: 34539376 PMCID: PMC8442768 DOI: 10.3389/fnagi.2021.682388

Abstract

It is known that aging is frequently accompanied by a decline in cognition. Furthermore, aging is associated with lower serum IGF-I levels that may contribute to this deterioration. We studied the effect of IGF-I in neurons of the horizontal diagonal band of Broca (HDB) of young (≤6 months old) and old (≥20-month-old) mice to determine if changes in the response of these neurons to IGF-I occur along with aging. Local injection of IGF-I in the HDB nucleus increased their neuronal activity and induced fast oscillatory activity in the electrocorticogram (ECoG). Furthermore, IGF-I facilitated tactile responses in the primary somatosensory cortex elicited by air-puffs delivered in the whiskers. These excitatory effects decreased in old mice. Immunohistochemistry showed that cholinergic HDB neurons express IGF-I receptors and that IGF-I injection increased the expression of c-fos in young, but not in old animals. IGF-I increased the activity of optogenetically-identified cholinergic neurons in young animals, suggesting that most of the IGF-I-induced excitatory effects were mediated by activation of these neurons. Effects of aging were partially ameliorated by chronic IGF-I treatment in old mice. The present findings suggest that reduced IGF-I activity in old animals participates in age-associated changes in cortical activity.

Copyright © 2021 Zegarra-Valdivia, Chaves-Coira, Fernandez de Sevilla, Martinez-Rachadell, Esparza, Torres-Aleman and Nuñez.

Keywords: IGF-I; aging; cholinergic neurons; cortical activity; diagonal band of Broca

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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