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Tarawneh O, Hamadneh I, Huwaitat R, et al. Characterization of Chlorhexidine-Impregnated Cellulose-Based Hydrogel Films Intended for the Treatment of Periodontitis. Biomed Res Int. 2021;2021:9853977doi: 10.1155/2021/9853977.
Tarawneh, O., Hamadneh, I., Huwaitat, R., Al-Assi, A. R., & El Madani, A. (2021). Characterization of Chlorhexidine-Impregnated Cellulose-Based Hydrogel Films Intended for the Treatment of Periodontitis. BioMed research international, 20219853977. https://doi.org/10.1155/2021/9853977
Tarawneh, Ola, et al. "Characterization of Chlorhexidine-Impregnated Cellulose-Based Hydrogel Films Intended for the Treatment of Periodontitis." BioMed research international vol. 2021 (2021): 9853977. doi: https://doi.org/10.1155/2021/9853977
Tarawneh O, Hamadneh I, Huwaitat R, Al-Assi AR, El Madani A. Characterization of Chlorhexidine-Impregnated Cellulose-Based Hydrogel Films Intended for the Treatment of Periodontitis. Biomed Res Int. 2021 Sep 15;2021:9853977. doi: 10.1155/2021/9853977. eCollection 2021. PMID: 34568496; PMCID: PMC8457944.
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Biomed Res Int. 2021 Sep 15;2021:9853977. doi: 10.1155/2021/9853977. eCollection 2021.

Characterization of Chlorhexidine-Impregnated Cellulose-Based Hydrogel Films Intended for the Treatment of Periodontitis.

BioMed research international

Ola Tarawneh, Imad Hamadneh, Rawan Huwaitat, Ameen Rasheed Al-Assi, Abdulla El Madani

Affiliations

  1. Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman 11733, Jordan.
  2. Chemistry Department, Faculty of Science, The University of Jordan, 11942 Amman, Jordan.

PMID: 34568496 PMCID: PMC8457944 DOI: 10.1155/2021/9853977

Abstract

Periodontitis comprises a chronic inflammation that is initiated by microbiota biofilm. If left untreated, periodontitis may lead to permanent tooth loss. Herein, we propose to design and improve a localized form of therapy comprising a chlorhexidine-impregnated hydrogel. Hydrogel films were prepared by varying the ratio between cellulose (MCC) and carboxymethylcellulose sodium (CMC) using the crosslinker epichlorohydrin (ECH). The hydrogel was loaded with chlorhexidine. Increasing the CMC ratio led to a reduction in the number of pores, an increase in their size, lower glass transition temperature (

Copyright © 2021 Ola Tarawneh et al.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

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