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Gülen D, Şafak B, Erdal B, et al. Curcumin-meropenem synergy in carbapenem resistant . Iran J Microbiol. 2021;13(3):345-351doi: 10.18502/ijm.v13i3.6397.
Gülen, D., Şafak, B., Erdal, B., & Günaydın, B. (2021). Curcumin-meropenem synergy in carbapenem resistant . Iranian journal of microbiology, 13(3), 345-351. https://doi.org/10.18502/ijm.v13i3.6397
Gülen, Dumrul, et al. "Curcumin-meropenem synergy in carbapenem resistant ." Iranian journal of microbiology vol. 13,3 (2021): 345-351. doi: https://doi.org/10.18502/ijm.v13i3.6397
Gülen D, Şafak B, Erdal B, Günaydın B. Curcumin-meropenem synergy in carbapenem resistant . Iran J Microbiol. 2021 Jun;13(3):345-351. doi: 10.18502/ijm.v13i3.6397. PMID: 34540173; PMCID: PMC8416589.
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Iran J Microbiol. 2021 Jun;13(3):345-351. doi: 10.18502/ijm.v13i3.6397.

Curcumin-meropenem synergy in carbapenem resistant .

Iranian journal of microbiology

Dumrul Gülen, Birol Şafak, Berna Erdal, Betül Günaydın

Affiliations

  1. Department of Medical Microbiology, Tekirda? Nam?k Kemal University, Faculty of Medicine, Tekirda?, Turkey.

PMID: 34540173 PMCID: PMC8416589 DOI: 10.18502/ijm.v13i3.6397

Abstract

BACKGROUND AND OBJECTIVES: The frequency of multiple resistant bacterial infections, including carbapenems, is increasing worldwide. As the decrease in treatment options causes difficulties in treatment, interest in new antimicrobials is increasing. One of the promising natural ingredients is curcumin. It is known to be effective in bacteria such as

MATERIALS AND METHODS: Thirty-nine

RESULTS: Synergistic effects were observed in 4 isolates producing MBL, 3 isolates producing KPC, 4 isolates producing OXA-48, and 1 isolates producing AmpC (totally 12 isolates) according to the calculated FICI. No antagonistic effects were observed in any isolates.

CONCLUSION: Curcumin was thought to be an alternative antimicrobial in combination therapies that would positively contribute to the treatment of bacterial infection. The effectiveness of this combination should be confirmed by other

Copyright © 2021 The Authors. Published by Tehran University of Medical Sciences.

Keywords: Anti-bacterial agents; Carbapenemase; Curcumin; Drug synergism; Klebsiella pneumoniae

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