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Miloradovic D, Pavlovic D, Jankovic MG, et al. Human Embryos, Induced Pluripotent Stem Cells, and Organoids: Models to Assess the Effects of Environmental Plastic Pollution. Front Cell Dev Biol. 2021;9:709183doi: 10.3389/fcell.2021.709183.
Miloradovic, D., Pavlovic, D., Jankovic, M. G., Nikolic, S., Papic, M., Milivojevic, N., Stojkovic, M., & Ljujic, B. (2021). Human Embryos, Induced Pluripotent Stem Cells, and Organoids: Models to Assess the Effects of Environmental Plastic Pollution. Frontiers in cell and developmental biology, 9709183. https://doi.org/10.3389/fcell.2021.709183
Miloradovic, Dragana, et al. "Human Embryos, Induced Pluripotent Stem Cells, and Organoids: Models to Assess the Effects of Environmental Plastic Pollution." Frontiers in cell and developmental biology vol. 9 (2021): 709183. doi: https://doi.org/10.3389/fcell.2021.709183
Miloradovic D, Pavlovic D, Jankovic MG, Nikolic S, Papic M, Milivojevic N, Stojkovic M, Ljujic B. Human Embryos, Induced Pluripotent Stem Cells, and Organoids: Models to Assess the Effects of Environmental Plastic Pollution. Front Cell Dev Biol. 2021 Sep 03;9:709183. doi: 10.3389/fcell.2021.709183. eCollection 2021. PMID: 34540831; PMCID: PMC8446652.
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Front Cell Dev Biol. 2021 Sep 03;9:709183. doi: 10.3389/fcell.2021.709183. eCollection 2021.

Human Embryos, Induced Pluripotent Stem Cells, and Organoids: Models to Assess the Effects of Environmental Plastic Pollution.

Frontiers in cell and developmental biology

Dragana Miloradovic, Dragica Pavlovic, Marina Gazdic Jankovic, Sandra Nikolic, Milos Papic, Nevena Milivojevic, Miodrag Stojkovic, Biljana Ljujic

Affiliations

  1. Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
  2. Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
  3. Laboratory for Bioengineering, Department of Science, Institute for Information Technologies, University of Kragujevac, Kragujevac, Serbia.
  4. SPEBO Medical Fertility Hospital, Leskovac, Serbia.

PMID: 34540831 PMCID: PMC8446652 DOI: 10.3389/fcell.2021.709183

Abstract

For a long time, animal models were used to mimic human biology and diseases. However, animal models are not an ideal solution due to numerous interspecies differences between humans and animals. New technologies, such as human-induced pluripotent stem cells and three-dimensional (3D) cultures such as organoids, represent promising solutions for replacing, refining, and reducing animal models. The capacity of organoids to differentiate, self-organize, and form specific, complex, biologically suitable structures makes them excellent

Copyright © 2021 Miloradovic, Pavlovic, Jankovic, Nikolic, Papic, Milivojevic, Stojkovic and Ljujic.

Keywords: bioinformatics; drug screening; early development; environmental pollution; model disease; organoids

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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