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World J Clin Oncol. 2021 Sep 24;12(9):800-807. doi: 10.5306/wjco.v12.i9.800.

Long-term results of the treatment of Hodgkin's lymphoma in a resource-constrained setting: Real-world data from a single center.

World journal of clinical oncology

Luisa Fernanda Sánchez-Valledor, Thomas M Habermann, Iván Murrieta-Alvarez, Alejandra Carmina Córdova-Ramírez, Montserrat Rivera-Álvarez, Andrés León-Peña, Yahveth Cantero-Fortiz, Juan Carlos Olivares-Gazca, Guillermo José Ruiz-Delgado, Guillermo José Ruiz-Argüelles

Affiliations

  1. Escuela de Medicina, Universidad de las Américas Puebla, Cholula 72810, Puebla, Mexico.
  2. Department of Medicine, Division of Hematology, Mayo Clinical and Mayo Foundation, Rochester, MN 55905, United States.
  3. Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla 72530, Mexico.
  4. Escuela de Medicina, Universidad Popular Autónoma del Estado de Puebla, Puebla 72410, Mexico.
  5. Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla 72530, Mexico. [email protected].

PMID: 34631443 PMCID: PMC8479346 DOI: 10.5306/wjco.v12.i9.800

Abstract

BACKGROUND: The outcomes of Hodgkin´s lymphoma (HL) in México have not been widely reported. Simplified and affordable treatments have been adopted in middle-income countries.

AIM: The aim was to evaluate long-used therapies for HL in México in a long-term basis.

METHODS: In a 34-year time period, 88 patients with HL were treated at a single institution in México. Patients were treated with adriamycin bleomycin vinblastine and dacarbazine (ABVD) or mechlorethamine, vincristine, procarbazine, and prednisone (MOPP). Relapsed or refractory patients were given ifosfamide, carboplatin, and etoposide (ICE) followed by autologous or allogeneic stem cell transplants.

RESULTS: Thirty-seven women and 51 men were included; the median age was 29 years. Patients were followed for a mean of 128 mo. The 310-mo overall survival (OS) was 83% for patients treated with MOPP and 88% for those treated with ABVD. The OS of patients who received autologous stem cell transplantation was 76% (330 mo)

CONCLUSION: HL may be less aggressive in Mexican population than in Caucasians. Combined chemotherapy renders acceptable results, regardless of clinical stage.

©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

Keywords: ABVD chemotherapy; Hodgkin; Lymphoma; Treatment

Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflicting interests.

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