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Cho J, Tsugawa Y, Imai Y, et al. Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy. Biochem Biophys Res Commun. 2021;579:110-115doi: 10.1016/j.bbrc.2021.09.039.
Cho, J., Tsugawa, Y., Imai, Y., & Imai, T. (2021). Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy. Biochemical and biophysical research communications, 579110-115. https://doi.org/10.1016/j.bbrc.2021.09.039
Cho, Jaeyong, et al. "Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy." Biochemical and biophysical research communications vol. 579 (2021): 110-115. doi: https://doi.org/10.1016/j.bbrc.2021.09.039
Cho J, Tsugawa Y, Imai Y, Imai T. Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy. Biochem Biophys Res Commun. 2021 Nov 19;579:110-115. doi: 10.1016/j.bbrc.2021.09.039. Epub 2021 Sep 24. PMID: 34597993; PMCID: PMC8568302.
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Biochem Biophys Res Commun. 2021 Nov 19;579:110-115. doi: 10.1016/j.bbrc.2021.09.039. Epub 2021 Sep 24.

Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy.

Biochemical and biophysical research communications

Jaeyong Cho, Yoji Tsugawa, Yumi Imai, Takeshi Imai

Affiliations

  1. Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu, Aichi, 474-8511, Japan. Electronic address: [email protected].
  2. Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu, Aichi, 474-8511, Japan. Electronic address: [email protected].
  3. Department of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA. Electronic address: [email protected].
  4. Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu, Aichi, 474-8511, Japan. Electronic address: [email protected].

PMID: 34597993 PMCID: PMC8568302 DOI: 10.1016/j.bbrc.2021.09.039

Abstract

The liver increases its size during pregnancy to adapt to metabolic demand associated with pregnancy. Our previous study showed that proliferation of maternal hepatocytes are increased during pregnancy in mice and that estradiol (E2) is one of the candidate hormones responsible for maternal hepatocyte proliferation. Here, we discovered that chorionic gonadotropin (CG) induces maternal hepatocyte proliferation during pregnancy. CG administration was sufficient to stimulate hepatocyte proliferation in non-pregnant mice as well as in cell culture system. We conclude that CG stimulates proliferation in the early pregnancy of maternal hepatocytes. In contrast, estrogen stimulates hepatocyte proliferation in the late pregnancy.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Apoptosis; Chorionic gonadotropin; Estrogen; Estrogen receptor; Hepatocyte; Placental lactogen; Ploidy; Pregnancy

Conflict of interest statement

Declaration of competing interest The authors declare no competing interests.

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