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Sobotta FH, Kuchenbrod MT, Gruschwitz FV, et al. Tuneable Time Delay in the Burst Release from Oxidation-Sensitive Polymersomes Made by PISA. Angew Chem Int Ed Engl. 2021;60(46):24716-24723doi: 10.1002/anie.202108928.
Sobotta, F. H., Kuchenbrod, M. T., Gruschwitz, F. V., Festag, G., Bellstedt, P., Hoeppener, S., & Brendel, J. C. (2021). Tuneable Time Delay in the Burst Release from Oxidation-Sensitive Polymersomes Made by PISA. Angewandte Chemie (International ed. in English), 60(46), 24716-24723. https://doi.org/10.1002/anie.202108928
Sobotta, Fabian H, et al. "Tuneable Time Delay in the Burst Release from Oxidation-Sensitive Polymersomes Made by PISA." Angewandte Chemie (International ed. in English) vol. 60,46 (2021): 24716-24723. doi: https://doi.org/10.1002/anie.202108928
Sobotta FH, Kuchenbrod MT, Gruschwitz FV, Festag G, Bellstedt P, Hoeppener S, Brendel JC. Tuneable Time Delay in the Burst Release from Oxidation-Sensitive Polymersomes Made by PISA. Angew Chem Int Ed Engl. 2021 Nov 08;60(46):24716-24723. doi: 10.1002/anie.202108928. Epub 2021 Oct 11. PMID: 34542227; PMCID: PMC8596869.
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Angew Chem Int Ed Engl. 2021 Nov 08;60(46):24716-24723. doi: 10.1002/anie.202108928. Epub 2021 Oct 11.

Tuneable Time Delay in the Burst Release from Oxidation-Sensitive Polymersomes Made by PISA.

Angewandte Chemie (International ed. in English)

Fabian H Sobotta, Maren T Kuchenbrod, Franka V Gruschwitz, Grit Festag, Peter Bellstedt, Stephanie Hoeppener, Johannes C Brendel

Affiliations

  1. Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743, Jena, Germany), E-mail: J. C. Brendel.
  2. Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.

PMID: 34542227 PMCID: PMC8596869 DOI: 10.1002/anie.202108928

Abstract

Reactive polymersomes represent a versatile artificial cargo carrier system that can facilitate an immediate release in response to a specific stimulus. The herein presented oxidation-sensitive polymersomes feature a time-delayed release mechanism in an oxidative environment, which can be precisely adjusted by either tuning the membrane thickness or partial pre-oxidation. These polymeric vesicles are conveniently prepared by PISA allowing the straightforward and effective in situ encapsulation of cargo molecules, as shown for dyes and enzymes. Kinetic studies revealed a critical degree of oxidation causing the destabilization of the membrane, while no release of the cargo is observed beforehand. The encapsulation of glucose oxidase directly transforms these polymersomes into glucose-sensitive vesicles, as small molecules including sugars can passively penetrate their membrane. Considering the ease of preparation, these polymersomes represent a versatile platform for the confinement and burst release of cargo molecules after a precisely adjustable time span in the presence of specific triggers, such as H

© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

Keywords: Vesicles; dispersion polymerization; nanoreactor; permeable membrane; thioether

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